Mitochondrial DNA Haplogroup | Haplogroup frequency, No. (%) | PSP versus controls | CBD versus controls | ||||
---|---|---|---|---|---|---|---|
Controls (N = 910) | PSP patients (N = 1042) | CBD patients (N = 171) | OR (95% CI) | P value | OR (95% CI) | P value | |
Na | 2 (0.2%) | 0 (0.0%) | 0 (0.0%) | – | – | – | – |
N1 | 5 (0.5%) | 6 (0.6%) | 0 (0.0%) | 1.08 (0.33, 3.58) | 0.90 | – | – |
I | 31 (3.4%) | 23 (2.2%) | 2 (1.2%) | 0.56 (0.32, 0.98) | 0.041 | 0.24 (0.06, 1.05) | 0.058 |
W | 15 (1.6%) | 22 (2.1%) | 3 (1.8%) | 1.37 (0.70, 2.67) | 0.36 | 1.27 (0.35, 4.54) | 0.72 |
X | 8 (0.9%) | 18 (1.7%) | 5 (2.9%) | 1.90 (0.81, 4.43) | 0.14 | 3.48 (1.07, 11.33) | 0.039 |
R and R0a | 6 (0.7%) | 10 (1.0%) | 2 (1.2%) | 1.33 (0.48, 3.72) | 0.58 | – | – |
HV and HV0a | 22 (2.4%) | 16 (1.5%) | 2 (1.2%) | 0.67 (0.35, 1.30) | 0.24 | 0.54 (0.12, 2.35) | 0.41 |
H, H1, H2, H3, and H4 | 423 (46.5%) | 469 (45.0%) | 84 (49.1%) | 0.94 (0.78, 1.13) | 0.50 | 1.11 (0.79, 1.55) | 0.54 |
H | 199 (21.9%) | 200 (19.2%) | 30 (17.5%) | 0.84 (0.68, 1.05) | 0.14 | 0.76 (0.49, 1.17) | 0.21 |
H1 | 145 (15.9%) | 171 (16.4%) | 31 (18.1%) | 1.03 (0.80, 1.31) | 0.84 | 1.16 (0.75, 1.79) | 0.52 |
H2 | 36 (4.0%) | 34 (3.3%) | 5 (2.9%) | 0.78 (0.48, 1.27) | 0.32 | 0.65 (0.25, 1.73) | 0.39 |
H3 | 32 (3.5%) | 49 (4.7%) | 9 (5.3%) | 1.47 (0.93, 2.33) | 0.10 | 1.76 (0.81, 3.83) | 0.16 |
H4 | 11 (1.2%) | 15 (1.4%) | 9 (5.3%) | 1.18 (0.54, 2.60) | 0.68 | 4.51 (1.8, 11.31) | 0.001 |
V | 18 (2.0%) | 29 (2.8%) | 3 (1.8%) | 1.37 (0.75, 2.50) | 0.31 | 0.79 (0.23, 2.79) | 0.72 |
JTa | 2 (0.2%) | 3 (0.3%) | 0 (0.0%) | – | – | – | – |
J1, J1d, J2a, and J2b | 93 (10.2%) | 125 (12.0%) | 18 (10.5%) | 1.23 (0.92, 1.64) | 0.15 | 1.11 (0.65, 1.92) | 0.70 |
J1 | 72 (7.9%) | 98 (9.4%) | 17 (9.9%) | 1.23 (0.89, 1.69) | 0.21 | 1.35 (0.76, 2.39) | 0.30 |
J1da | 1 (0.1%) | 0 (0.0%) | 0 (0.0%) | – | – | – | – |
J2a | 13 (1.4%) | 24 (2.3%) | 1 (0.6%) | 1.77 (0.89, 3.53) | 0.10 | 0.49 (0.06, 3.84) | 0.50 |
J2b | 7 (0.8%) | 3 (0.3%) | 0 (0.0%) | 0.39 (0.10, 1.52) | 0.17 | – | – |
T, T1, and T2 | 77 (8.5%) | 102 (9.8%) | 22 (12.9%) | 1.20 (0.88, 1.64) | 0.26 | 1.72 (1.02, 2.89) | 0.042 |
Ta | 0 (0.0%) | 2 (0.2%) | 1 (0.6%) | – | – | – | – |
T1 | 17 (1.9%) | 22 (2.1%) | 4 (2.3%) | 1.10 (0.58, 2.10) | 0.77 | 1.16 (0.37, 3.6) | 0.80 |
T2 | 60 (6.6%) | 78 (7.5%) | 17 (9.9%) | 1.19 (0.84, 1.70) | 0.33 | 1.74 (0.97, 3.11) | 0.063 |
U, U1, U3, U5, and U6 | 130 (14.3%) | 138 (13.2%) | 19 (11.1%) | 0.88 (0.68, 1.15) | 0.36 | 0.71 (0.42, 1.19) | 0.19 |
U | 44 (4.8%) | 56 (5.4%) | 7 (4.1%) | 1.07 (0.71, 1.61) | 0.74 | 0.84 (0.36, 1.92) | 0.68 |
U1a | 1 (0.1%) | 1 (0.1%) | 0 (0.0%) | – | – | – | – |
U3a | 8 (0.9%) | 0 (0.0%) | 0 (0.0%) | – | – | – | – |
U5 | 74 (8.1%) | 80 (7.7%) | 12 (7.0%) | 0.92 (0.66, 1.28) | 0.60 | 0.79 (0.41, 1.51) | 0.48 |
U6a | 3 (0.3%) | 1 (0.1%) | 0 (0.0%) | – | – | – | – |
K | 78 (8.6%) | 80 (7.7%) | 11 (6.4%) | 0.92 (0.66, 1.28) | 0.62 | 0.72 (0.37, 1.41) | 0.35 |