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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice

Fig. 8

Effect of LM11A-31 treatment on behavior. a Distance moved in open field testing. Statistical significance between groups was analyzed by three-way ANOVA. Group effect for genotype, p < 0.0001; n = 22–26 mice per group. b Vertical time monitoring. Statistical significance between groups was analyzed by restricted maximum likelihood model. Group effect for genotype, p < 0.0001; n = 22-26 mice per group. c Elevated-plus maze analysis. Statistical significance was determined using Kruskal–Wallis with post hoc Dunn’s testing; n = 25 mice per group; p-values are indicated. d Morris Water Maze, learning phase assessed with escape latency assessment. Statistical significance between groups was analyzed by three-way ANOVA. Group effect for genotype, p = 0.0112; n = 11–13 mice per group. e Probe trial testing. Pairwise target versus non-target significance was determined with Mann–Whitney testing, p-values are indicated; n = 11–13 mice per group. f Novel place recognition testing. Familiar versus novel place recognition assessed using paired t testing, p values are indicated, n = 23–25 mice per group. g Novel place recognition discrimination index. Statistical significance was determined using ANOVA with post hoc Sidak’s multiple comparison testing; n = 23–25 mice per group. h Contextual fear conditioning, trace analysis. Statistical significance was determined using Kruskal–Wallis with post hoc Dunn’s testing; n = 23–25 mice per group. i Contextual and cued memory testing

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