Skip to main content
Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice

Fig. 7

Effect of LM11A-31 treatment on survival. a Body weight monitoring demonstrates reduced weights in Tg mice. Statistical significance between groups was analyzed by mixed effects analysis. Group effect for genotype, p < 0.0001; n = 32–33 mice per group. b Survival analysis of cohorts treated 6–9 months with study terminated at 9 months of age. Data from two independent treatment cohorts is combined. LM11A-31 treated Tg mice demonstrated a reduced death rate compared to vehicle-treated Tg mice. Statistical significance was determined using the log-rank (Mantel-Cox) test; Ntg-V, n = 32–33 mice per group, p-value comparisons are indicated. c Survival analysis of mice with treatment starting at age 6 months, with termination of study at 481 days of age. Statistical significance was determined using the log-rank (Mantel-Cox) test; n = 12–13 mice per group, p-value comparisons are indicated

Back to article page