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Table 2 APOE genotypes and allele frequencies by pathologically defined groups

From: Assessment of genetic risk for improved clinical-neuropathological correlations

  N (%)
APOE genotype frequency ε4 allele frequency
2/2 2/3 2/4 3/3 3/4 4/4
Control 1 (1) 25 (14) 7 (4) 119 (67) 24 (14) 1 (1) 33 (9)
FTD 0 (0) 7 (11) 1 (2) 37 (58) 19 (30) 0 (0) 20 (16)†
DLB 0 (0) 8 (14) 4 (7) 28 (50) 16 (29) 0 (0) 20 (18)*†
AD + DLB 2 (0) 11 (2) 5 (1) 136 (31) 224 (51) 64 (14) 357 (40)*
AD 0 (0) 52 (3) 51 (3) 594 (33) 829 (46) 273 (15) 1426 (40)*
AD + MTLS 0 (0) 8 (5) 5 (3) 58 (33) 83 (47) 21 (12) 130 (37)*
  1. APOE ε4 allele frequency was different between pathologically defined groups (overall χ2 = 174.5, p < .001). FDR adjusted p < .05 for differences from *Control, †All AD groups (AD, AD + DLB, and AD + MTLS) based on pairwise Chi squared tests
  2. Abbreviations: DLB, dementia with Lewy bodies; AD, Alzheimer’s disease; FTD, frontotemporal lobar degeneration; MTLS, medial temporal lobe sclerosis; APOE, apolipoprotein E