Fig. 2

Relationship between polygenic scores and pathological variables. Graphical visualization of the relationship between the PD, DLB, and AD polygenic scores and measures of AD (Braak stage and neuritic plaque density) and Lewy pathology. Results of ordinal and binary logistic regression models for each polygenic score and pathological outcome variable are included in Table 3. *The number of participants is reported for the AD PHS and PD PRS analyses. The DLB PRS was analyzed in a subset of 2282 total participants. Abbreviations: PD, Parkinson’s disease, PRS, polygenic risk score; DLB, dementia with Lewy bodies; AD, Alzheimer’s disease; PHS, polygenic hazard score; BP, brainstem predominant; LT, limbic (transitional); DN, diffuse neocortical