Table 1 Disease and survival data of seed inoculated hSOD1G85R Tg mice receiving systemic administration of mAbs
No mAb control | αSOD165–72 (10 mg/kg) | αSOD165–72 (50 mg/kg) | αSOD1143–153 (10 mg/kg) | αSOD1143–153 (50 mg/kg) | pAb IgG (50 mg/kg) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | days | n | days | n | days | n | days | n | days | n | days | |
Age at 1st mAb injection | – | – | 5 | 76 ± 2 | 5 | 76 ± 2 | 5 | 79 | 9 | 79 ± 3 | 9 | 78 ± 3 |
Age at SOD1G85R seed inoculation | 9 | 100 ± 4 | 5 | 98 ± 2 | 5 | 99 ± 2 | 5 | 101 ± 1 | 9 | 101 ± 3 | 9 | 100 ± 3 |
Paralytic end-stage (days post-inoculation) | 9 | 94 ± 14 | 5 | 88 ± 24 | 5 | 78 ± 2 | 5 | 118 ± 35 | 9 | 185 ± 101 | 9 | 113 ± 59 |
Symptom onset (days post-inoculation) | 6 | 69 ± 13 | 5 | 73 ± 17 | 5 | 62 ± 5 | 5 | 100 ± 25 | 9 | 175 ± 102 | 9 | 101 ± 63 |
Age at paralytic end-stage | 9 | 195 ± 13 | 5 | 187 ± 26 | 5 | 177 ± 3** | 5 | 219 ± 35 | 9 | 286 ± 100**, * | 9 | 214 ± 58 |