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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Proteogenomic analysis of melanoma brain metastases from distinct anatomical sites identifies pathways of metastatic progression

Fig. 3

Pathway Analysis identifies PI3KCG as upregulated in MBM tissue. a Canonical pathways downregulated in the metastatic brain tumors. b Canonical pathways upregulated in the metastatic brain tumors. c PIK3CG expression in the cancer genome atlas melanoma cohort demonstrates significantly decreased expression in primary tumor tissue in comparison to metastatic tissue (p = 4.77 × 10−15). d Heatmap of proteins in common among the G beta gamma, CXCR4, and thrombin signaling pathways significantly increased levels of PI3KCG protein in the MBMs compared to the primary tumor

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