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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Proteogenomic analysis of melanoma brain metastases from distinct anatomical sites identifies pathways of metastatic progression

Fig. 2

Proteogenomics demonstrate that MBMs cluster with each other. a Volcano plots of proteomics data. Proteins with fold changes significantly greater or less than 2 are highlighted as red and blue markers, respectively. b MD plots of RNA-sequencing data. Gene transcripts with probability > 0.90 are highlighted as red and blue markers, respectively. c Heatmap of differentially expressed proteins and genes that overlapped between the proteomics and RNA-sequencing data sets. Hierarchial clustering demonstrates that MBM cluster together and separately from the primary tumor. BM 2 and BM3 are the most similar amongst the MBM

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