Skip to main content
Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Proteogenomic analysis of melanoma brain metastases from distinct anatomical sites identifies pathways of metastatic progression

Fig. 1

Clinical Course, Radiological Imaging and Phylogeny of Patient with 3 anatomically distinct melanoma brain metastases. a Timeline summarizing clinical course from diagnosis to death. Red lines denote the surgical resections during which tissue samples were obtained for proteogenomics. b Post contrast axial T1 MR images of Brain Metastases (BM) 1, 2, and 3, which were surgically removed. BM 4 and BM 5 were treated with radiation. c Tumor phylogeny shows the accumulated and shared mutations and copy number events gained during evolution from original germline (GL) cells to primary and metastatic tumors. Each node represents a new clonal lineage and is marked with the number of new SNVs observed. The treemaps show the proportion of each clone of which each sample was composed

Back to article page
\