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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila

Fig. 2

Pan-neuronal expression of 1000 repeat DPRs alters longevity but not viability. a Mating scheme for Drosophila viability assays. Flies homozygous for the UAS-GFP-DPR constructs were crossed to flies carrying the pan-neuronal driver (nSyb-Gal4) over the Tm6b balancer chromosome. Normal mendelian inheritance should result in a 50:50 ratio of flies carrying both the driver and DPR (pan-neuronally driven DPR) and those carrying only the DPR in the absence of the driver (undriven siblings). b pan-neuronal expression of each DPR line following the mating scheme in “a” shows no significant variance in viability compared to GFP (mCD8-GFP) controls or to the expected 50:50 ratio. Two independent lines of each DPR are shown. N is shown above each bar. c flies pan-neuronally expressing GR1000 show a significant reduction in longevity compared to wild type and control flies (Survival Log-Rank (Mantel-Cox) with Bonferroni Correction, *** p < .001 (See Additional file 1: Online resource 6)). N: wild type (WT) = 96, GFP = 98, AP = 100, GA = 111, PR = 119, GR = 90. All flies in “b” and “c” were collected from at least 3 independent crosses

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