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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor

Fig. 3

Histologic spectrum of epigenetically defined rosette-forming glioneuronal tumors harboring FGFR1 kinase domain hotspot missense mutations (p.N546 or p.K656) in combination with PIK3CA or PIK3R1 mutation. These tumors are characterized by a glial component typically with oligodendroglial morphology together with an admixed neurocytic component consisting of neurocytic rosettes and/or perivascular neuropil, frequently in a mucin-rich stroma

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