Skip to main content
Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure

Fig. 5

Western blot and immune electron microscopy of aggregated tau protein. a Sarkosyl-insoluble fractions of brain tissue lysates from the frontal cortex (Fr) and caudate nucleus of our patient were subjected to western blot analysis. Patients with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) were also assessed for comparison. Western blot analysis using anti-T46 antibody exhibited bands prominent at 64 kDa, 68 kDa, 33 kDa, and 37 kDa. The bands at 33 kDa and 37 kDa were equally intense in our patient, whereas those at 33 kDa or 37 kDa were prominent in the patient with PSP or CBD, respectively. b, c The sarkosyl-insoluble fraction contained ribbon-like filaments with long periodicity, which were immunopositive for AT8 (b) and an anti-Tau C antibodies (c). Scale bars = 100 nm, original magnification × 60,000

Back to article page