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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma

Fig. 1

Histological and immunohistochemical analysis in patient UPN#171 a Hematoxylin/Eosin staining (original magnification 200X): enlarged neoplastic cells with multiple, often bizarre, hyperchromatic nuclei and high number of mitoses. Vascular proliferation, as seen in these “glomeruloids” (lower half of the image), is a specific pattern of microvascular growth; b Hematoxylin/Eosin staining (original magnification 400X): multiple mitotic figures are evident in the middle field. “Geographic pattern” of necrosis (detail in insert panel b); c Positive GFAP staining highlights high neoplastic cells with astrocytic differentiation; d Intense and diffuse nuclear TP53 staining

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