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Table 1 List of 25 genes up-regulated in the brains of CBE-treated mice but not in SVNI-infected mice

From: Innate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis

 

SVNI versus control

CBE versus control

CBE + SVNI versus control

Statistically significant difference between CBE and SVNI

 Fcrls

0.2¶ ± 0.0

3.5 ± 0.2

2.4 ± 0.1

 Gpr34

0.5¶ ± 0.1

2.1 ± 0.2

1.5 ± 0.1

 Trem2

0.7 ± 0.1

5.5 ± 0.4

3.6 ± 0.8

 Cx3cr1

0.9 ± 0.1

2.5 ± 0.1

2.0 ± 0.3

 Ifi27

0.9 ± 0.1

2.6 ± 0.1

2.4 ± 0.3

 Siglech

1.0 ± 0.3

2.2 ± 0.2

1.9 ± 0.4

 Hexa

1.2 ± 0.1

2.1 ± 0.1

1.7 ± 0.2

 H2-Ob

1.2 ± 0.4

4.5 ± 0.8

4.3 ± 0.9

 Itgb5

1.3 ± 0.2

2.3 ± 0.1

1.9 ± 0.3

 Csf1r

1.3 ± 0.2

2.5 ± 0.1

2.2 ± 0.4

 Cybrd1*

1.3 ± 0.4

3.2 ± 0.5

2.4 ± 0.5

 Cd33

1.3 ± 0.3

2.9 ± 0.2

2.5 ± 0.6

 Hpgds

1.3 ± 0.2

2.7 ± 0.3

1.9 ± 0.4

 Ctsd

1.4 ± 0.1

3.1 ± 0.3

2.2 ± 0.4

 Hexb

1.5 ± 0.2

3.2 ± 0.3

2.7 ± 0.6

 Spp1

1.5 ± 0.0

2.1 ± 0.3

1.5 ± 0.2

 Gusb

1.7 ± 0.1

2.4 ± 0.4

2.0 ± 0.4

 Capn3

1.9 ± 0.3

2.6 ± 0.2

2.3 ± 0.3

 H2-Oa

2.0 ± 1.2

5.5 ± 0.2

4.9 ± 1.5

 Lpar5

2.1 ± 0.2

3.0 ± 0.2

2.7 ± 0.4

 Lilra5

2.1 ± 0.1

6.4 ± 1.0

4.5 ± 1.4

Not statistically significant difference between CBE and SVNI

 Ang

1.7 ± 0.5

2.4 ± 0.6

1.7 ± 0.6

 Abcc3

1.7 ± 0.2

2.3 ± 0.4

2.1 ± 0.4

 Lpcat2

1.9 ± 0.2

2.1 ± 0.1

1.9 ± 0.4

 Arhgap19

1.8 ± 0.2

2.1 ± 0.3

1.8 ± 0.3

  1. RNAseq analysis of brains of control, SVNI, CBE, and CBE + SVNI mice 5 DPI. The numbers indicates fold-change versus control
  2. ¶Significantly down-regulated (≥ 2.0, fdr ≤ 0.05). Genes in bold font indicate higher expression levels in microglia than all other non-myeloid cells in the CNS. Italicized genes also indicate enrichment in microglia over other myeloid cells
  3. *Expression at or more highly in astrocytes than other cells in the CNS