Fig. 7
From: Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain
Phosphorylation occupancies of insoluble pS202 correlate more with soluble pT217 phosphorylation rates, than Abeta42. a Phosphorylation occupancy at T217 in brain soluble extracts showed a non-linear correlation (i.e., exponential-plateau) with pS202 in insoluble extracts (R2 = 0.81 plateauing at 51%). b Abeta 42 did not correlate with pS202% in insoluble extracts from Abeta+ brain samples (R2 = 0.51 plateauing at 50%). A total of 28 brain soluble- and insoluble-matched extracts were analyzed from two Abeta+ brains (regions: CB, SFG, Temp, Ocp, Amy, Pari, and Striatum from one case; CB, SFG, Temp, Ocp, Amy, Pari, and Striatum from the other participant) and two AD participants (regions: SFG, Temp, Ocp, Amy, Pari, and Striatum from one participant; CB, SFG, Temp, Ocp, Amy, Pons, Pari, and Striatum from the other case). Regression curves depict an exponential plateau model. Red squares and blue circles are individual data from AD and Abeta brains, respectively. Open data points indicate the data from CB regions containing low amyloid pathology