Fig. 3
From: Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain
Mapping tau phosphorylation in AD brain soluble and insoluble fractions compared to CSF. Schematics of tau phosphorylation occupancies in AD CSF and brain. Tau phosphorylation occupancies in the control (a) and AD (b) CSF [3]. CSF tau is truncated after mid domain. Tau phosphorylation occupancies in control (c), AD soluble (d) and insoluble (e) brain fractions. T111, T153, S205 T175, S184 (or S185), S208, T217, S262, S285 are hyperphosphorylated (AD/control fold ratio > 2) in AD brain soluble tau (from brain homogenate). Phosphorylation occupancies at T111(0N), S113 (0N), T153, T181, S199, S202, T205, T217, T231, S262 and S396 are particularly increased in AD insoluble brain fractions and show a change according to the disease progression