Fig. 4
From: Ovine congenital progressive muscular dystrophy (OCPMD) is a model of TNNT1 congenital myopathy
Type I OCPMD myofibres initiate force generation at twofold lower Ca2+ concentration than wild-type fibres. Physical and physiological properties of single type I fibres from type I myofibre-predominant muscles (anconeus) of wild-type (WT) and affected (AF) sheep, including (a) fibre cross-sectional area (CSA), b maximal specific force, c force-pCa curve relating force generation to − log(10) of the calcium concentration (pCa), and (d) pCa plot of calcium concentration (mM) required to generate 10% (pCa10), 20% (pCa20), and 50% (pCa50) of maximal force. Statistical differences between wild-type and affected samples were assessed using a two-tailed, unpaired t-test; ns: not significant, ****p < 0.0001