Assessment of radial glia in the frontal lobe of fetuses with Down syndrome

Table 4 Morphology parameters of GFAP and Vimentin labelled radial glia in the Down syndrome and age-matched Euploid brain

Cases	PMA	GFAP						Vimentin
		oSVZ			IZ			oSVZ			IZ
		Circularity	Area (µm²)	Length (µm)	Circularity	Area (µm²)	Length (µm)	Circularity	Area (µm²)	Length (µm)	Circularity	Area (µm²)	Length (µm)
Age-matched euploid control
E-1	18 + 0	0.25	57.98	14.14	0.26	21.64	9.32	0.24	57.13	14.04	0.28	38.65	11.38
E-2	22 + 2	0.22	47.14	14.14	0.23	31.82	12.19	0.23	45.79	13.59	0.25	29.50	11.04
E-3	23 + 0	0.20	44.31	15.20	0.16	25.17	13.80	0.20	61.98	17.16	0.21	40.24	14.62
E-4	23 + 2	0.30	34.43	10.71	0.33	23.14	8.69	0.32	28.86	9.55	0.30	38.10	10.93
E-5	24 + 1	0.35	26.08	8.65	0.43	16.99	6.34	0.34	30.07	9.22	0.33	20.67	8.17
E-6	24 + 2	0.38	31.71	9.12	0.37	22.57	8.09	x	x	x	x	x	x
Down syndrome
DS-1	15 + 6	0.31	49.33	12.44	0.28	42.60	11.40	0.33	32.23	10.17	0.33	24.64	8.97
DS-2	18 + 4	0.22	47.21	14.48	0.20	34.91	12.85	0.20	75.37	19.35	0.16	48.23	17.78
DS-3	19 + 5	0.31	42.52	11.81	0.33	24.87	9.54	0.27	49.87	13.82	0.32	19.80	8.36
DS-4	21 + 1	0.27	29.35	10.17	0.30	21.56	8.65	0.45	24.86	7.59	0.42	24.88	7.93
DS-5	22 + 5	0.29	60.14	13.30	0.27	37.66	13.88	0.32	49.83	13.39	0.33	47.42	13.01

Length, Area and Circularity measured in the oSVZ and IZ across mid-gestation. X; Not assessed

ISSN: 2051-5960