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Table 3 CRYAB and HOPX staining in the Ventricular and Subventricular Zones during mid-gestation in Down syndrome and age-matched euploid control brains

From: Assessment of radial glia in the frontal lobe of fetuses with Down syndrome

Cases PMA (weeks + days) CRYAB HOPX
VZ/iSVZ oSVZ VZ/iSVZ oSVZ
Aged-match euploid control
E-1 18 + 0 Peri-nuclear, along ventricle X Sparse Yes
E-2 22 + 2 Peri-nuclear, heterogeneous expression continuous radial projection Sparse Yes
E-3 23 + 0 Peri-nuclear, along ventricle X Sparse Yes
E-4 23 + 2 Peri-nuclear, along ventricle Punctate radial projections Sparse Yes
E-5 24 + 1 Strong radial, away from ventricle - perinuclear, tails to positive cells X Sparse Yes
Down syndrome
DS-1 15 + 6 X X Sparse Yes
DS-2 18 + 4 Peri-nuclear and radial X Sparse Yes
DS-5 19 + 5 Peri-nuclear along ventricle Punctate radial projections Sparse Yes
DS-4 21 + 1 Cellular, peri-nuclear and radial Punctate radial projections Sparse Yes
DS-5 22 + 5 X X Sparse Yes
DS-6 23 + 4 X X Sparse Yes
  1. E euploid, DS down syndrome, PMA post-menstrual age, VZ ventricular zone, iSVZ inner subventricular zone, oSVZ subventricular zone. X = no positive staining present, Sparse = few cells; yes = frequent number of cells
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