Table 1 Down syndrome (DS) and age-matched euploid control case details. Summary of clinical case information of human post-mortem cases from age-matched Euploid and DS fetuses
From: Assessment of radial glia in the frontal lobe of fetuses with Down syndrome
Case | Sex | GA at birth (weeks) | Delivery status | Postnatal age | PMA at death (weeks + days) | Birth weight (g) | Congenital heart defects & clinical context | Neuropathology |
|---|---|---|---|---|---|---|---|---|
Aged-matched euploid control | ||||||||
E-1 | M | 18 + 0 | IUD/STILLBIRTH | x | 18 + 0 | 130 | Chronic histiocytic intervillostitis | None |
E-2 | M | 22 + 2 | TOP | x | 22 + 2 | 402 | Hypoplastic left heart syndrome | None |
E-3 | M | 23 + 0 | IUD/MISC | x | 23 + 0 | 570 | Probable cervical incompetence, congenital pneumonia | None |
E-4 | M | 23 + 2 | NND | 5 m | 23 + 2 | 531.84 | Associated IUGR, oligohydramnios, congestive heart failure | None |
E-5 | F | 24 + 1 | NND | 4 h 40 m | 24 + 1 | 660 | Extreme prematurity, congestive heart failure | None |
E-6 | M | 24 + 2 | IUD/STILLBIRTH | x | 24 + 2 | 738 | Constricted umbilical cord, congestive heart failure | None |
E-7 | M | 38 + 4 | IUD/STILLBIRTH | x | 38 + 4 | 2690 | symmetrical IUGR, cord entanglement/obstruction | None |
E-8 | F | 38 + 6 | NND | 3d | 39 + 1 | 2640 | Hypolobated lungs with marked lymphangiectasia and meconium in terminal air spaces | None |
E-9 | M | 39 + 2 | IUD/STILLBIRTH | x | 39 + 2 | 3125 | Not identified | None |
Down syndrome | ||||||||
DS-1 | M | 15 + 6 | TOP | x | 15 + 6 | 76.9 | None | None |
DS-2 | F | 18 + 4 | TOP | X | 18 + 4 | 178.1 | Multiple malformations including: Pulmonary stenosis, membranous VSD | None |
DS-3 | F | 19 + 5 | TOP | X | 19 + 5 | 260 | None | None |
DS-4 | M | 21 + 1 | TOP | X | 21 + 1 | 429.3 | Multiple malformations including: peri-membranous VSD | None |
DS-5 | F | 22 + 5 | TOP | X | 22 + 5 | 420 | None | Focal periventricular haemorrhages |
DS-6 | F | 23 + 4 | TOP | X | 23 + 4 | 850 | None | None |
DS-7 | M | 37 + 5 | NND | 1d 14 h 53 m | 38 + 0 | 3980 | lung hypoplasia | WM gliosis, perivascular haemorrhages |
DS-8 | M | 38 + 6 | NND | 11 h 37 m | 38 + 6 | 3630 | HIE, myeloproliferative disorder | HIE Grade III |
DS-9 | F | 32 + 4 | INFANT DEATH | 6wks 6d | 39 + 4 | 2658 | Necrotizing Enterocolitis | Patchy WM gliosis |