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Table 1 Down syndrome (DS) and age-matched euploid control case details. Summary of clinical case information of human post-mortem cases from age-matched Euploid and DS fetuses

From: Assessment of radial glia in the frontal lobe of fetuses with Down syndrome

Case Sex GA at birth (weeks) Delivery status Postnatal age PMA at death (weeks + days) Birth weight (g) Congenital heart defects & clinical context Neuropathology
Aged-matched euploid control
E-1 M 18 + 0 IUD/STILLBIRTH x 18 + 0 130 Chronic histiocytic intervillostitis None
E-2 M 22 + 2 TOP x 22 + 2 402 Hypoplastic left heart syndrome None
E-3 M 23 + 0 IUD/MISC x 23 + 0 570 Probable cervical incompetence, congenital pneumonia None
E-4 M 23 + 2 NND 5 m 23 + 2 531.84 Associated IUGR, oligohydramnios, congestive heart failure None
E-5 F 24 + 1 NND 4 h 40 m 24 + 1 660 Extreme prematurity, congestive heart failure None
E-6 M 24 + 2 IUD/STILLBIRTH x 24 + 2 738 Constricted umbilical cord, congestive heart failure None
E-7 M 38 + 4 IUD/STILLBIRTH x 38 + 4 2690 symmetrical IUGR, cord entanglement/obstruction None
E-8 F 38 + 6 NND 3d 39 + 1 2640 Hypolobated lungs with marked lymphangiectasia and meconium in terminal air spaces None
E-9 M 39 + 2 IUD/STILLBIRTH x 39 + 2 3125 Not identified None
Down syndrome
DS-1 M 15 + 6 TOP x 15 + 6 76.9 None None
DS-2 F 18 + 4 TOP X 18 + 4 178.1 Multiple malformations including: Pulmonary stenosis, membranous VSD None
DS-3 F 19 + 5 TOP X 19 + 5 260 None None
DS-4 M 21 + 1 TOP X 21 + 1 429.3 Multiple malformations including: peri-membranous VSD None
DS-5 F 22 + 5 TOP X 22 + 5 420 None Focal periventricular haemorrhages
DS-6 F 23 + 4 TOP X 23 + 4 850 None None
DS-7 M 37 + 5 NND 1d 14 h 53 m 38 + 0 3980 lung hypoplasia WM gliosis, perivascular haemorrhages
DS-8 M 38 + 6 NND 11 h 37 m 38 + 6 3630 HIE, myeloproliferative disorder HIE Grade III
DS-9 F 32 + 4 INFANT DEATH 6wks 6d 39 + 4 2658 Necrotizing Enterocolitis Patchy WM gliosis
  1. F Female, HIE hypoxic-ischemic encephalopathy, IUD intrauterine death, IUGR intrauterine growth restrictions, M Male, NND neonatal death, PMA post-menstrual age, TOP termination of pregnancy, m minutes, h hours, d day, wks weeks, VSD Ventricular septal defect, WM white matter. X indicates not applicable. None indicates structurally normal with no overt pathology/injury
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