Fig. 3

SOX2 cells in the oSVZ and IZ in mid-gestation. The number of SOX2 positive cells in the (A) oSVZ and (D) IZ across mid-gestation in age-matched euploid (black squares) and Down syndrome (grey circles) cases. Photomicrographs of SOX2 staining in the (B, C) iSVZ/oSVZ and (E, F) IZ in (B, E) euploid, 22⁺² weeks PMA and Down syndrome, 21⁺¹ weeks PMA. Scale bars indicate (B, C, E, F) 150 µm, (i) 5 µm. Abbreviations: IZ; intermediate zone, SVZ; subventricular zone (iSVZ; inner, oSVZ; outer), PMA; post-menstrual age