Fig. 2

CRYAB and HOPX in the developing brain. Photomicrographs of CRYAB (apical/ventral/truncated radial glia), and HOPX (basal/outer radial glia) in coronal frontal lobe sections in mid-gestation from (A, B) age-matched euploid, 22⁺² weeks PMA and (C, D) Down syndrome 19⁺⁵ weeks PMA. (E–H) In late-gestation CRYAB and HOPX staining is cellular in both Down syndrome (38⁺⁴ weeks PMA) and euploid (39⁺¹ weeks PMA) cases. Scale bars indicate (A–D) 500 µm, (i–iii) 50 µm, (E–H) 100 µm. Abbreviations: LV; lateral ventricle, SVZ; subventricular zone (iSVZ; inner, oSVZ; outer), PMA; post-menstrual age, VZ; ventricular zone