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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Assessment of radial glia in the frontal lobe of fetuses with Down syndrome

Fig. 2

CRYAB and HOPX in the developing brain. Photomicrographs of CRYAB (apical/ventral/truncated radial glia), and HOPX (basal/outer radial glia) in coronal frontal lobe sections in mid-gestation from (A, B) age-matched euploid, 22+2 weeks PMA and (C, D) Down syndrome 19+5 weeks PMA. (EH) In late-gestation CRYAB and HOPX staining is cellular in both Down syndrome (38+4 weeks PMA) and euploid (39+1 weeks PMA) cases. Scale bars indicate (AD) 500 µm, (i–iii) 50 µm, (EH) 100 µm. Abbreviations: LV; lateral ventricle, SVZ; subventricular zone (iSVZ; inner, oSVZ; outer), PMA; post-menstrual age, VZ; ventricular zone

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