Fig. 5
From: Tau reduction in aged mice does not impact Microangiopathy
Increased cell adhesion protein expression in tau expressing mice. a Quantitative PCR revealed an increase in Vcam1 (Two-way ANOVA, age p = 0.0117, genotype p = 0.0002, interaction p = 0.01), Icam1 (age p < 0.0001, genotype p < 0.0001, interaction p < 0.0001), and Icam2 (age p < 0.04, genotype p < 0.004, interaction p = 0.05). Increased expression was observed in transgenic 12-month mice and 15-month mice; Sidak’s multiple comparisons p-values are indicated. b Doxycycline treated and untreated transgenic mice had elevated Vcam1 (Two-way ANOVA, genotype p < 0.0001, treatment p = 0.06, interaction p = 0.56), Icam1 (genotype p = 0.002, treatment p = 0.90, interaction p = 0.94) and Serpine1 (genotype p = 0.02, treatment p = 0.16, interaction p = 0.19), but not Icam2 (genotype p = 0.13, treatment p = 0.50, interaction p = 0.74). Untreated 15-month mice are the same in panels (a) and (b). RQ = relative quatification using comparative Ct method. All graphs are plotted with means +/− standard deviations. * indicates p < 0.05, ** p < 0.01