Fig. 4
From: Tau reduction in aged mice does not impact Microangiopathy
Vascular remodeling is not altered in mice with reduced tau burden. a 100 μm thick z-projection images of fluorescein-labeled vasculature from wild-type (WT) and transgenic (TG) mice captured by two-photon microscopy. b The volume of blood vessels in each mouse was calculated and normalized to the cortical thickness to account for atrophy. Blood vessel volume was increased in transgenic mice and was not altered by treatment (Two-way ANOVA, genotype p = 0.04, treatment p = 0.4). c Total blood vessel length was also increased in transgenics (Two-way ANOVA, genotype p = 0.007, treatment p = 0.74). d The total percentage of all vessels imaged without red blood cell flow was also increased (Two-way ANOVA, genotype p < 0.0001, treatment p = 0.19). All graphs are plotted with means +/− standard deviations. * indicates p < 0.05, ** p < 0.01, ***p < 0.001