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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Lipid-specific IgMs induce antiviral responses in the CNS: implications for progressive multifocal leukoencephalopathy in multiple sclerosis

Fig. 4

O4 induces cell type specific patterns of ISG expression in the CNS. a-i DIV24 rat cultures treated 24 h with A4CD or O4. a Table showing differential cellular expression of ISGs. Data analysed by paired two-tailed t-test. Significant differences denoted by *p < 0.05 and **p < 0.01. n = 3. b, c GFAP (astrocytes) and Cxcl10 in A4CD and O4-treated cultures respectively. (d, e) NeuN (neurons) and Rsad2 in A4CD and O4-treated cultures respectively. f, g Olig2 (oligodendrocytes) and Mx1 in A4CD and O4-treated cultures respectively. h, i Iba1 (microglia) and Oasl in A4CD and O4-treated cultures respectively

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