Fig. 2

IPAD in hippocampus. (a -c) The distribution of amyloid-β in relation to collagen IV and smooth muscle actin at 7 min after intrahippocampal injection. c & d) Amyloid-β (red) was observed diffusely distributed in the parenchyma and co-localised (pink colour) with collagen IV in the walls of arterioles (white arrows), capillaries (yellow arrow) and few venules (green arrow). Representative high power image of an arteriole (e-h) shows amyloid-β (red) (g-h) in the wall of the blood vessel, indicated by the white arrow in (h). Scale bars a-d = 200 μm, e – h = 10 μm