Skip to main content

Table 4 Pathology features in muscle biopsies from JDM patients with Mi2, NXP2 and MDA5 autoantibodies

From: Distinct tissue injury patterns in juvenile dermatomyositis auto-antibody subgroups

Histology Mi2 (n = 4) NXP2 (n = 4) MDA5 (n = 2) p value
K-W1
p value
M-W2
CD3 endomysial (0/1/2) 3/1/0 2/2/0 2/0/0 0.4720 0.5357
CD3 perimysial (0/1/2) 1/0/3 1/0/3 2/0/0 0.1850 1.0000
CD3 perivascular (0/1/2) 0/1/3 1/0/3 2/0/0 0.1083 0.8687
Macrophages endomysial (0/1/2) 0/0/4 0/3/1 1/1/0 0.0377 0.0632
Macrophages perimysial (0/1/2) 0/1/3 0/3/1 1/1/0 0.1136 0.2248
Macrophages perivascular (0/1/2) 1/2/1 0/3/1 2/0/0 0.1228 0.6446
Capillary TRI (EM) (0/1/2) 0/1/2 0/0/4 2/0/0 0.0970 0.3778
Arterial abnormal (0/1) 0/4 1/3 2/0 0.0554 0.4497
Infarction (0/1) 4/0 3/1 2/0 0.4724 0.4497
MHC-1 upregulation (0/1) 0/4 0/3 1/1 0.1738 1.0000
Atrophy perifascicular (0/1/2) 0/1/3 0/1/3 2/0/0 0.0601 1.0000
Atrophy non-perifascicular (0/1) 2/2 3/1 2/0 0.4724 0.5357
Type IIc fibers (0/1) 1/3 1/3 2/0 0.1850 1.0000
Degeneratinga fibers perifascicular (0/1/2) 0/1/3 0/3/1 2/0/0 0.0498 0.2248
Degeneratinga fibers non-perifascicular (0/1/2 2/1/1 1/2/1 2/0/0 0.3221 0.6612
Internal nuclei (0/1) 2/2 3/1 2/0 0.4724 0.5357
Fibrosis endomysial (0/1) 2/2 3/1 2/0 0.4724 0.5357
Fibrosis perimysial (0/1) 1/3 1/3 2/0 0.1850 1.0000
ALK perimysium (0/1/2) 0/1/3 3/1/0 2/0 0.0271 0.0284
C5b-9 myofiber (0/1/2) 0/0/3 1/3/0 2/0/0 0.0219 0.0308
C5b-9 capillary (0/1/2) 2/1/0 0/0/4 2/0/0 0.0180 0.0277
  1. 1: p-values calculated by Kruskal-Wallis test among the Mi-2, NXP-2 and MDA5 mono-autoantibody groups. Patients with multiple autoantibodies were excluded
  2. 2: p-values calculated by Mann-Whitney test between the Mi-2 and NXP-2 mono-autoantibody groups. Patients with multiple autoantibodies were excluded
  3. a: These include degenerating fibers, regenerating fibers and necrotic fibers