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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity

Fig. 3

HEX co-expression rescues aSYN-associated loss of nigrostriatal TH content. a Representative immunofluorescent micrograph showing TH (greyscale) in the striata of rats injected with AAV6-CTRL+aSYN or aSYN+HEX. Dashed red lines indicate the dorsolateral aspect of the caudate-putamen (b) Representative micrograph of TH-DAB stained SNpc in rats injected with AAV6-CTRL+aSYN or aSYN+HEX. Boxed inserts are shown in higher magnification below. (c) Densitometric quantifications of average TH+ immunofluorescence intensity measured in the indicated regions, presented as in (a). *:p < 0.05, Welch’s t-test, n = 6 and 9 / group). d Unbiased stereological estimates of # TH+ cell profiles per SNpc, expressed as % of the non-injected hemisphere per animal (dotted line). *:p < 0.05, Welch’s t-test, n = 6 and 9 / group). Data represent median, 95%CI and range, with individual data points shown. e Pearson’s correlation analysis of TH+ cell counts from (d) with average striatal aSYN+ immunofluorescence (AFUs) in the region indicated in (a) (N = 13)

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