Fig. 3

Insoluble tau levels are significantly reduced in JNPL3 brains. a In the JNPL3 mice, insoluble tau (INS) was significantly reduced in cortex (ctx) in the AAV1-CAG-scFvMC1 group (scFvMC1) (n = 13) compared to the AAV1-CAG-eGFP injected cohort (Controls) (n = 13). Both total and phosphorylated tau (three different epitopes pThr231, pSer202 and pSer396/404) were significantly reduced (***p < 0.001; ****p < 0.0001; non parametric Mann-Whitney test). b Total and pSer396/404 insoluble tau were unchanged in the JNPL3 hindbrain (HB) in the treated scFvMC1 mice (n = 13) compared to the controls (n = 13); on the contrary, tau phosphorylated at pThr231, pSer202 exhibited a significant decrease (*p < 0.05; **p < 0.01, non parametric Mann-Whitney test). Graphs are expressed as % Control, and means +/− SEM