TY - JOUR AU - Wang, Y. AU - Mandelkow, E. PY - 2016 DA - 2016// TI - Tau in physiology and pathology JO - Nat Rev Neurosci VL - 17 ID - Wang2016 ER - TY - JOUR AU - Cleveland, D. W. AU - Hwo, S. Y. AU - Kirschner, M. W. PY - 1977 DA - 1977// TI - Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly JO - J Mol Biol VL - 116 ID - Cleveland1977 ER - TY - JOUR AU - Buée, L. PY - 2000 DA - 2000// TI - Tau protein isoforms, phosphorylation and role in neurodegenerative disorders JO - Brain Res Brain Res Rev VL - 33 ID - Buée2000 ER - TY - JOUR AU - Mandelkow, E. M. AU - Mandelkow, E. PY - 2012 DA - 2012// TI - Biochemistry and cell biology of tau protein in neurofibrillary degeneration JO - Cold Spring Harb Perspect Med VL - 2 ID - Mandelkow2012 ER - TY - JOUR AU - Rösler, T. W. PY - 2019 DA - 2019// TI - Four-repeat tauopathies JO - Prog Neurobiol VL - 180 ID - Rösler2019 ER - TY - JOUR AU - Frost, B. AU - Jacks, R. L. AU - Diamond, M. I. PY - 2009 DA - 2009// TI - Propagation of tau misfolding from the outside to the inside of a cell JO - J Biol Chem VL - 284 ID - Frost2009 ER - TY - JOUR AU - Clavaguera, F. PY - 2009 DA - 2009// TI - Transmission and spreading of tauopathy in transgenic mouse brain JO - Nat Cell Biol VL - 11 ID - Clavaguera2009 ER - TY - JOUR AU - Wu, J. W. PY - 2013 DA - 2013// TI - Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons JO - J Biol Chem VL - 288 ID - Wu2013 ER - TY - JOUR AU - Clavaguera, F. PY - 2014 DA - 2014// TI - Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice JO - Acta Neuropathol VL - 127 ID - Clavaguera2014 ER - TY - JOUR AU - Clavaguera, F. AU - Grueninger, F. AU - Tolnay, M. PY - 2014 DA - 2014// TI - Intercellular transfer of tau aggregates and spreading of tau pathology: implications for therapeutic strategies JO - Neuropharmacology VL - 76 Pt A ID - Clavaguera2014 ER - TY - JOUR AU - Clavaguera, F. PY - 2013 DA - 2013// TI - Brain homogenates from human tauopathies induce tau inclusions in mouse brain JO - Proc Natl Acad Sci U S A VL - 110 ID - Clavaguera2013 ER - TY - JOUR AU - Calignon, A. PY - 2012 DA - 2012// TI - Propagation of tau pathology in a model of early Alzheimer's disease JO - Neuron VL - 73 ID - Calignon2012 ER - TY - JOUR AU - Colin, M. PY - 2020 DA - 2020// TI - From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy JO - Acta Neuropathol VL - 139 ID - Colin2020 ER - TY - JOUR AU - d'Abramo, C. PY - 2013 DA - 2013// TI - Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity JO - PLoS One VL - 8 ID - d'Abramo2013 ER - TY - JOUR AU - d'Abramo, C. PY - 2015 DA - 2015// TI - Passive immunization in JNPL3 transgenic mice using an Array of Phospho-tau specific antibodies JO - PLoS One VL - 10 ID - d'Abramo2015 ER - TY - JOUR AU - Chai, X. PY - 2011 DA - 2011// TI - Passive immunization with anti-tau antibodies in two transgenic models: reduction of tau pathology and delay of disease progression JO - J Biol Chem VL - 286 ID - Chai2011 ER - TY - JOUR AU - Boutajangout, A. PY - 2011 DA - 2011// TI - Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain JO - J Neurochem VL - 118 ID - Boutajangout2011 ER - TY - JOUR AU - Boutajangout, A. AU - Quartermain, D. AU - Sigurdsson, E. M. PY - 2010 DA - 2010// TI - Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model JO - J Neurosci VL - 30 ID - Boutajangout2010 ER - TY - JOUR AU - Asuni, A. A. PY - 2007 DA - 2007// TI - Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements JO - J Neurosci VL - 27 ID - Asuni2007 ER - TY - JOUR AU - Sankaranarayanan, S. PY - 2015 DA - 2015// TI - Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models JO - PLoS One VL - 10 ID - Sankaranarayanan2015 ER - TY - JOUR AU - Castillo-Carranza, D. L. PY - 2014 DA - 2014// TI - Passive immunization with tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles JO - J Neurosci VL - 34 ID - Castillo-Carranza2014 ER - TY - JOUR AU - Albert, M. PY - 2019 DA - 2019// TI - Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody JO - Brain VL - 142 ID - Albert2019 ER - TY - JOUR AU - Yanamandra, K. PY - 2015 DA - 2015// TI - Anti-tau antibody reduces insoluble tau and decreases brain atrophy JO - Ann Clin Transl Neurol VL - 2 ID - Yanamandra2015 ER - TY - JOUR AU - Yanamandra, K. PY - 2013 DA - 2013// TI - Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo JO - Neuron VL - 80 ID - Yanamandra2013 ER - TY - JOUR AU - Courade, J. P. PY - 2018 DA - 2018// TI - Epitope determines efficacy of therapeutic anti-tau antibodies in a functional assay with human Alzheimer tau JO - Acta Neuropathol VL - 136 ID - Courade2018 ER - TY - JOUR AU - Dai, C. L. PY - 2018 DA - 2018// TI - Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated tau-induced pathology in 3 × Tg-AD mice JO - Alzheimers Res Ther VL - 10 ID - Dai2018 ER - TY - JOUR AU - Pardridge, W. M. PY - 2012 DA - 2012// TI - Drug transport across the blood-brain barrier JO - J Cereb Blood Flow Metab VL - 32 ID - Pardridge2012 ER - TY - JOUR AU - Pardridge, W. M. PY - 2009 DA - 2009// TI - Alzheimer's disease drug development and the problem of the blood-brain barrier JO - Alzheimers Dement VL - 5 ID - Pardridge2009 ER - TY - JOUR AU - Wilcock, D. M. AU - Colton, C. A. PY - 2009 DA - 2009// TI - Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice JO - CNS Neurol Disord Drug Targets VL - 8 ID - Wilcock2009 ER - TY - JOUR AU - Boche, D. PY - 2008 DA - 2008// TI - Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain JO - Brain VL - 131 ID - Boche2008 ER - TY - JOUR AU - Frenkel, D. AU - Katz, O. AU - Solomon, B. PY - 2000 DA - 2000// TI - Immunization against Alzheimer's beta -amyloid plaques via EFRH phage administration JO - Proc Natl Acad Sci U S A VL - 97 ID - Frenkel2000 ER - TY - JOUR AU - Liu, R. PY - 2004 DA - 2004// TI - Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity JO - Biochemistry VL - 43 ID - Liu2004 ER - TY - JOUR AU - Fukuchi, K. PY - 2006 DA - 2006// TI - Anti-Abeta single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's disease JO - Neurobiol Dis VL - 23 ID - Fukuchi2006 ER - TY - JOUR AU - Levites, Y. PY - 2006 DA - 2006// TI - Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice JO - J Neurosci VL - 26 ID - Levites2006 ER - TY - JOUR AU - Wang, Y. J. PY - 2009 DA - 2009// TI - Intramuscular delivery of a single chain antibody gene reduces brain Abeta burden in a mouse model of Alzheimer's disease JO - Neurobiol Aging VL - 30 ID - Wang2009 ER - TY - JOUR AU - Ryan, D. A. PY - 2010 DA - 2010// TI - Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice JO - Mol Ther VL - 18 ID - Ryan2010 ER - TY - JOUR AU - Wang, X. P. PY - 2009 DA - 2009// TI - Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers JO - FEBS Lett VL - 583 ID - Wang2009 ER - TY - JOUR AU - Boado, R. J. PY - 2010 DA - 2010// TI - IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey JO - Biotechnol Bioeng VL - 105 ID - Boado2010 ER - TY - JOUR AU - Fernandez-Funez, P. PY - 2015 DA - 2015// TI - Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in drosophila models of Alzheimer's disease JO - Hum Mol Genet VL - 24 ID - Fernandez-Funez2015 ER - TY - JOUR AU - Liu, W. PY - 2016 DA - 2016// TI - Vectored intracerebral immunization with the anti-tau monoclonal antibody PHF1 markedly reduces tau pathology in mutant tau transgenic mice JO - J Neurosci VL - 36 ID - Liu2016 ER - TY - JOUR AU - Gallardo, G. PY - 2019 DA - 2019// TI - Targeting tauopathy with engineered tau-degrading intrabodies JO - Mol Neurodegener VL - 14 ID - Gallardo2019 ER - TY - JOUR AU - Ising, C. PY - 2017 DA - 2017// TI - Correction: AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy JO - J Exp Med VL - 214 ID - Ising2017 ER - TY - JOUR AU - Vitale, F. PY - 2018 DA - 2018// TI - Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice JO - Acta Neuropathol Commun VL - 6 ID - Vitale2018 ER - TY - JOUR AU - Spencer, B. PY - 2018 DA - 2018// TI - Selective targeting of 3 repeat tau with brain penetrating single chain antibodies for the treatment of neurodegenerative disorders JO - Acta Neuropathol VL - 136 ID - Spencer2018 ER - TY - JOUR AU - Yang, J. PY - 2013 DA - 2013// TI - Muscle-directed anti-Aβ single-chain antibody delivery via AAV1 reduces cerebral Aβ load in an Alzheimer's disease mouse model JO - J Mol Neurosci VL - 49 ID - Yang2013 ER - TY - JOUR AU - Bird, R. E. PY - 1988 DA - 1988// TI - Single-chain antigen-binding proteins JO - Science VL - 242 ID - Bird1988 ER - TY - JOUR AU - Huston, J. S. PY - 1993 DA - 1993// TI - Medical applications of single-chain antibodies JO - Int Rev Immunol VL - 10 ID - Huston1993 ER - TY - JOUR AU - Holliger, P. AU - Hudson, P. J. PY - 2005 DA - 2005// TI - Engineered antibody fragments and the rise of single domains JO - Nat Biotechnol VL - 23 ID - Holliger2005 ER - TY - JOUR AU - Wörn, A. AU - Plückthun, A. PY - 2001 DA - 2001// TI - Stability engineering of antibody single-chain Fv fragments JO - J Mol Biol VL - 305 ID - Wörn2001 ER - TY - JOUR AU - Arndt, K. M. AU - Müller, K. M. AU - Plückthun, A. PY - 1998 DA - 1998// TI - Factors influencing the dimer to monomer transition of an antibody single-chain Fv fragment JO - Biochemistry VL - 37 ID - Arndt1998 ER - TY - JOUR AU - Milone, M. C. AU - O'Doherty, U. PY - 2018 DA - 2018// TI - Clinical use of lentiviral vectors JO - Leukemia VL - 32 ID - Milone2018 ER - TY - STD TI - Rafii MS et al (2018) Adeno-associated viral vector (serotype 2)-nerve growth factor for patients with Alzheimer disease: a randomized clinical trial. JAMA Neurol 75(7):834-841 ID - ref52 ER - TY - JOUR AU - Herzog, C. D. PY - 2011 DA - 2011// TI - Gene transfer provides a practical means for safe, long-term, targeted delivery of biologically active neurotrophic factor proteins for neurodegenerative diseases JO - Drug Deliv Transl Res VL - 1 ID - Herzog2011 ER - TY - JOUR AU - LeWitt, P. A. PY - 2011 DA - 2011// TI - AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial JO - Lancet Neurol VL - 10 ID - LeWitt2011 ER - TY - JOUR AU - Hitti, F. L. PY - 2019 DA - 2019// TI - Human gene therapy approaches for the treatment of Parkinson's disease: an overview of current and completed clinical trials JO - Parkinsonism Relat Disord VL - 66 ID - Hitti2019 ER - TY - JOUR AU - McPhee, S. W. PY - 2006 DA - 2006// TI - Immune responses to AAV in a phase I study for Canavan disease JO - J Gene Med VL - 8 ID - McPhee2006 ER - TY - JOUR AU - Christine, C. W. PY - 2009 DA - 2009// TI - Safety and tolerability of putaminal AADC gene therapy for Parkinson disease JO - Neurology VL - 73 ID - Christine2009 ER - TY - JOUR AU - Mendell, J. R. PY - 2017 DA - 2017// TI - Single-dose gene-replacement therapy for spinal muscular atrophy JO - N Engl J Med VL - 377 ID - Mendell2017 ER - TY - JOUR AU - Rivière, C. AU - Danos, O. AU - Douar, A. M. PY - 2006 DA - 2006// TI - Long-term expression and repeated administration of AAV type 1, 2 and 5 vectors in skeletal muscle of immunocompetent adult mice JO - Gene Ther VL - 13 ID - Rivière2006 ER - TY - JOUR AU - Mueller, C. PY - 2017 DA - 2017// TI - 5 year expression and neutrophil defect repair after gene therapy in Alpha-1 antitrypsin deficiency JO - Mol Ther VL - 25 ID - Mueller2017 ER - TY - JOUR AU - Mueller, C. PY - 2013 DA - 2013// TI - Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression JO - J Clin Invest VL - 123 ID - Mueller2013 ER - TY - JOUR AU - Lewis, J. PY - 2000 DA - 2000// TI - Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein JO - Nat Genet VL - 25 ID - Lewis2000 ER - TY - JOUR AU - Allen, B. PY - 2002 DA - 2002// TI - Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein JO - J Neurosci VL - 22 ID - Allen2002 ER - TY - JOUR AU - Acker, C. M. PY - 2013 DA - 2013// TI - Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models JO - Neurobiol Aging VL - 34 ID - Acker2013 ER - TY - JOUR AU - Forest, S. K. PY - 2013 DA - 2013// TI - Methods for measuring tau pathology in transgenic mouse models JO - J Alzheimers Dis VL - 33 ID - Forest2013 ER - TY - JOUR AU - Schafer, D. P. PY - 2012 DA - 2012// TI - Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner JO - Neuron VL - 74 ID - Schafer2012 ER - TY - JOUR AU - Nestor, J. PY - 2018 DA - 2018// TI - Lupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitors JO - J Exp Med VL - 215 ID - Nestor2018 ER - TY - JOUR AU - Chan, K. PY - 2020 DA - 2020// TI - Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory JO - Nat Commun VL - 11 ID - Chan2020 ER - TY - JOUR AU - Greenberg, S. G. AU - Davies, P. PY - 1990 DA - 1990// TI - A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis JO - Proc Natl Acad Sci U S A VL - 87 ID - Greenberg1990 ER - TY - JOUR AU - Bennett, M. L. PY - 2016 DA - 2016// TI - New tools for studying microglia in the mouse and human CNS JO - Proc Natl Acad Sci U S A VL - 113 ID - Bennett2016 ER - TY - JOUR AU - d'Abramo, C. PY - 2016 DA - 2016// TI - Detecting tau in serum of transgenic animal models after tau immunotherapy treatment JO - Neurobiol Aging VL - 37 ID - d'Abramo2016 ER - TY - JOUR AU - Paul, S. M. PY - 2011 DA - 2011// TI - Therapeutic antibodies for brain disorders JO - Sci Transl Med VL - 3 ID - Paul2011 ER - TY - JOUR AU - Esquerda-Canals, G. AU - Martí-Clúa, J. AU - Villegas, S. PY - 2019 DA - 2019// TI - Pharmacokinetic parameters and mechanism of action of an efficient anti-Aβ single chain antibody fragment JO - PLoS One VL - 14 ID - Esquerda-Canals2019 ER - TY - JOUR AU - Bard, F. PY - 2000 DA - 2000// TI - Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease JO - Nat Med VL - 6 ID - Bard2000 ER - TY - JOUR AU - Thompson, E. J. AU - Keir, G. PY - 1990 DA - 1990// TI - Laboratory investigation of cerebrospinal fluid proteins JO - Ann Clin Biochem VL - 27 ID - Thompson1990 ER - TY - JOUR AU - Haidet, A. M. PY - 2008 DA - 2008// TI - Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors JO - Proc Natl Acad Sci U S A VL - 105 ID - Haidet2008 ER - TY - JOUR AU - Hammond, T. R. PY - 2019 DA - 2019// TI - Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes JO - Immunity VL - 50 ID - Hammond2019 ER - TY - JOUR AU - Hammond, T. R. AU - Robinton, D. AU - Stevens, B. PY - 2018 DA - 2018// TI - Microglia and the brain: complementary Partners in Development and Disease JO - Annu Rev Cell Dev Biol VL - 34 ID - Hammond2018 ER - TY - STD TI - Shi Y et al (2019) Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. J Exp Med 216(11):2546-2561 ID - ref79 ER - TY - JOUR AU - Bennett, R. E. PY - 2018 DA - 2018// TI - Partial reduction of microglia does not affect tau pathology in aged mice JO - J Neuroinflammation VL - 15 ID - Bennett2018 ER - TY - JOUR AU - Jicha, G. A. PY - 1997 DA - 1997// TI - Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau JO - J Neurosci Res VL - 48 ID - Jicha1997 ER - TY - JOUR AU - Bohlen, C. J. AU - Bennett, F. C. AU - Bennett, M. L. PY - 2019 DA - 2019// TI - Isolation and culture of microglia JO - Curr Protoc Immunol VL - 125 ID - Bohlen2019 ER - TY - JOUR AU - Bohlen, C. J. PY - 2017 DA - 2017// TI - Diverse requirements for microglial survival, specification, and function revealed by defined-medium cultures JO - Neuron VL - 94 ID - Bohlen2017 ER - TY - JOUR AU - DeMattos, R. B. PY - 2002 DA - 2002// TI - Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease JO - Science VL - 295 ID - DeMattos2002 ER - TY - JOUR AU - Nisbet, R. M. PY - 2017 DA - 2017// TI - Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model JO - Brain VL - 140 ID - Nisbet2017 ER - TY - JOUR AU - Freund, J. PY - 1930 DA - 1930// TI - Accumulation of antibodies in the central nervous system JO - J Exp Med VL - 51 ID - Freund1930 ER - TY - JOUR AU - Atwal, J. K. PY - 2011 DA - 2011// TI - A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo JO - Sci Transl Med VL - 3 ID - Atwal2011 ER - TY - JOUR AU - Meliani, A. PY - 2018 DA - 2018// TI - Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration JO - Nat Commun VL - 9 ID - Meliani2018 ER - TY - JOUR AU - Mingozzi, F. PY - 2007 DA - 2007// TI - CD8(+) T-cell responses to adeno-associated virus capsid in humans JO - Nat Med VL - 13 ID - Mingozzi2007 ER - TY - JOUR AU - Hui, D. J. PY - 2015 DA - 2015// TI - AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes JO - Mol Ther Methods Clin Dev VL - 2 ID - Hui2015 ER - TY - JOUR AU - Ferreira, V. PY - 2014 DA - 2014// TI - Immune responses to intramuscular administration of alipogene tiparvovec (AAV1-LPL(S447X)) in a phase II clinical trial of lipoprotein lipase deficiency gene therapy JO - Hum Gene Ther VL - 25 ID - Ferreira2014 ER - TY - JOUR AU - Gernoux, G. PY - 2020 DA - 2020// TI - Muscle-directed delivery of an AAV1 vector leads to capsid-specific T cell exhaustion in nonhuman primates and humans JO - Mol Ther VL - 28 ID - Gernoux2020 ER - TY - JOUR AU - Luo, W. PY - 2015 DA - 2015// TI - Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody JO - Sci Rep VL - 5 ID - Luo2015 ER - TY - JOUR AU - Guilbaud, M. PY - 2019 DA - 2019// TI - Five years of successful inducible transgene expression following Locoregional adeno-associated virus delivery in nonhuman primates with no detectable immunity JO - Hum Gene Ther VL - 30 ID - Guilbaud2019 ER -