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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: A comprehensive DNA panel next generation sequencing approach supporting diagnostics and therapy prediction in neurooncology

Fig. 1

Overview of the DNA Panel NGS results. Molecular alterations per case are illustrated in form of an oncoprint figure [27]. The figure contains information on the histological diagnoses according to WHO 2016 criteria, molecular alterations, the presence of relapse as well as age and sex of the patients. A: astrocytoma, GB: glioblastoma, O: oligodendroglioma, pA: piloytic astrocytoma, MG_H3: diffuse midline glioma, H3K27M-mutant; M: meningioma; MB: medulloblastoma, wnt: WNT-activated, shh: SHH-activated, non: non-WNT/SHH. TRU: truncating variation probably leading to a loss of function, MUT: somatic missense variation, HIGHCOPY: highcopy amplification, AMP: amplification, HOMDEL: homozygous loss, DEL: deletion, LOH: loss of heterozygosity, MUTGER: germline SNP with minor allele frequencies for Europeans (non-Finnish) < 0.01 and number of homozygotes SNPs < 5

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