|
Cytokines/ Chemokines
|
Paraneoplastic anti-NMDARE (P, medium, range; pg/ml)
|
Anti-NMDARE without teratoma (N, medium, range; pg/ml)
|
Negative symptom control (C, medium, range; pg/ml)
|
P value
|
|---|
|
P vs Na
|
P vs Ca
|
|---|
|
TNF-α
|
3.19(2.83–3.55)
|
3.19(2.32–8.15)
|
2.49(1.84–3.55)
|
0.613
|
0.039
|
|
IFN-γ
|
47.68(46.03–59.35)
|
46.03(30.12–59.35)
|
42.77(37.94–57.67)
|
0.286
|
0.083
|
|
CXCL9
|
174(121–336)
|
227(121–443)
|
227(121–336)
|
0.246
|
0.724
|
|
CXCL10
|
69.03(3.53–147)
|
15.6(1.82–7002)
|
4.49(2.26–147)
|
0.793
|
0.088
|
|
IL-2
|
415(345–458)
|
460(318–630)
|
408(327–564)
|
0.324
|
0.831
|
|
IL-4
|
16.17(11.77–31.30)
|
26.07(11.77–49.06)
|
17.72(8.66–36.3)
|
0.099
|
0.914
|
|
IL-5
|
1.83(1.68–2.25)
|
1.97(1.13–4.5)
|
1.68(1.41–2.25)
|
0.732
|
0.424
|
|
GM-CSF
|
12.56(4.43–18.44)
|
5.31(2.77–69.48)
|
4(2.02–18.44)
|
0.356
|
0.025
|
|
G-CSF
|
26.07(15.37–30.44)
|
26.9(15.37–110)
|
27.62(18.59–41.01)
|
0.429
|
0.52
|
|
IL-6
|
1.33(0.88–11.33)
|
3.26(1.15–68.3)
|
1.73(1.15–11.33)
|
0.158
|
0.392
|
|
IL-8
|
50.79(17.89–87.97)
|
58.47(11.28–150)
|
25.54(3.96–87.97)
|
0.694
|
0.055
|
|
IL-17A
|
0.81(−0.81)
|
0.81(−5.02)
|
0.81(−2.79)
|
0.279
|
0.645
|
|
IL-10
|
6.09(4.89–7.58)
|
5.2 (2.16–22.88)
|
4.45(2.31–6.48)
|
0.393
|
0.033
|
|
APRIL
|
152(56.68–194)
|
147(48.19–973)
|
74.19(35.96–175)
|
0.767
|
0.134
|
|
BAFF
|
157.5(139–266)
|
189.5(68.03–1011)
|
266(174–314)
|
0.491
|
0.055
|
|
CXCL13
|
27.23(14.07–57.17)
|
29.67(11.48–507)
|
12.52(10.43–33.96)
|
0.818
|
0.055
|
|
CCL2
|
736.5(656–771)
|
788(293–1868)
|
852(447–2665)
|
0.491
|
0.286
|
|
CXCL1
|
52(−63.15)
|
63.15(23.42–170)
|
34.92(−71.33)
|
0.155
|
0.668
|
|
IFN-α
|
2.73(1.94–5.86)
|
3.19(1.7–8.29)
|
2.72(1.94–5.86)
|
0.576
|
0.914
|
|
IL-1α
|
43.7(32.68–45.56)
|
68.91(39.47–215)
|
39.47(34.04–50.27)
|
0.026
|
0.522
|
|
IL-1β
|
1.42(0.71–1.83)
|
1.42(0.71–2.96)
|
1.24(1.05–1.42)
|
0.567
|
0.489
|
|
IL-12
|
124.5(− 133)
|
101(− 307)
|
56.35(−133)
|
0.766
|
0.831
|
|
VEGF-A
|
36.65(26.66–45.66)
|
52.68(32.13–119)
|
42.65(16.95–52.68)
|
0.026
|
0.67
|
- P Paraneoplastic anti-NMDARE, N Anti-NMDARE without teratoma, C Negative control, CCL C-C motif chemokine ligand, CXCL C-X-C motif chemokine ligand, IFN interferon, IL interleukin, TNF tumour necrosis factor, VEGF vascular endothelial growth factor A, APRIL a proliferation-inducing ligand, BAFF B-cell-activating factor belonging to the tumour necrosis factor family, G-CSF granulocyte colony-stimulating factor, GM-CSF granulocyte-macrophage colony-stimulating factor
- aMann-Whitney U test and Bonferroni correction (α = 0.025)
