Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 159 patients

Table 4 NMDAR subunit analysis in neurons of teratomas with/without anti-NMDARE

Neuron morphology	Case	Neuron staining	NR1	NR2A	NR2B
Normal neurons	N1	NeuN+	+	++	+++
	N2	NeuN+	+	++	+
	N7	NeuN+	–	–	–
	N8	NeuN+	++	–	+++
	N10	NeuN+	–	–	–
	N11	NeuN+	+	+	+++
Mimicking floating-frog dysmorphic neurons	N4	NeuN+	+	++	+++
	N5–6	NeuN+	++	+++	+++
	N9	S100++ MAP2+	+	–	+++
Clusters of dysmorphic neurons	N2	NeuN+	+	+++	+++
	N3	NeuN+	–	+	++
	N7	NeuN+	++	++	++
	N10	NeuN+	+	+++	+++
Scattered dysmorphic neurons;	N1	NeuN+	+	++	+++
	N7	MAP2+	+	+++	++
	N8	NeuN+	++	+	+++

N1–11: patients with paraneoplastic anti-NMDARE; C1–12: patients without anti-NMDARE; −, positive cells less than 1% of microscopic field; + < 25%; ++, 25–50%; +++, 50–75%; ++++, > 75%. NeuN Neuronal Nuclear epitope, MAP2 Microtubule Associated Protein 2, GFAP Glial Fibrillary Acidic Protein, NR NMDA reception

ISSN: 2051-5960