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Table 4 NMDAR subunit analysis in neurons of teratomas with/without anti-NMDARE

From: Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 159 patients

Neuron morphology Case Neuron staining NR1 NR2A NR2B
Normal neurons N1 NeuN+ + ++ +++
N2 NeuN+ + ++ +
N7 NeuN+
N8 NeuN+ ++ +++
N10 NeuN+
N11 NeuN+ + + +++
Mimicking floating-frog dysmorphic neurons N4 NeuN+ + ++ +++
N5–6 NeuN+ ++ +++ +++
N9 S100++ MAP2+ + +++
Clusters of dysmorphic neurons N2 NeuN+ + +++ +++
N3 NeuN+ + ++
N7 NeuN+ ++ ++ ++
N10 NeuN+ + +++ +++
Scattered dysmorphic neurons; N1 NeuN+ + ++ +++
N7 MAP2+ + +++ ++
N8 NeuN+ ++ + +++
  1. N1–11: patients with paraneoplastic anti-NMDARE; C1–12: patients without anti-NMDARE; −, positive cells less than 1% of microscopic field; + < 25%; ++, 25–50%; +++, 50–75%; ++++, > 75%. NeuN Neuronal Nuclear epitope, MAP2 Microtubule Associated Protein 2, GFAP Glial Fibrillary Acidic Protein, NR NMDA reception