|
Neuron morphology
|
Case
|
Neuron staining
|
NR1
|
NR2A
|
NR2B
|
|---|
|
Normal neurons
|
N1
|
NeuN+
|
+
|
++
|
+++
|
|
N2
|
NeuN+
|
+
|
++
|
+
|
|
N7
|
NeuN+
|
–
|
–
|
–
|
|
N8
|
NeuN+
|
++
|
–
|
+++
|
|
N10
|
NeuN+
|
–
|
–
|
–
|
|
N11
|
NeuN+
|
+
|
+
|
+++
|
|
Mimicking floating-frog dysmorphic neurons
|
N4
|
NeuN+
|
+
|
++
|
+++
|
|
N5–6
|
NeuN+
|
++
|
+++
|
+++
|
|
N9
|
S100++ MAP2+
|
+
|
–
|
+++
|
|
Clusters of dysmorphic neurons
|
N2
|
NeuN+
|
+
|
+++
|
+++
|
|
N3
|
NeuN+
|
–
|
+
|
++
|
|
N7
|
NeuN+
|
++
|
++
|
++
|
|
N10
|
NeuN+
|
+
|
+++
|
+++
|
|
Scattered dysmorphic neurons;
|
N1
|
NeuN+
|
+
|
++
|
+++
|
|
N7
|
MAP2+
|
+
|
+++
|
++
|
|
N8
|
NeuN+
|
++
|
+
|
+++
|
- N1–11: patients with paraneoplastic anti-NMDARE; C1–12: patients without anti-NMDARE; −, positive cells less than 1% of microscopic field; + < 25%; ++, 25–50%; +++, 50–75%; ++++, > 75%. NeuN Neuronal Nuclear epitope, MAP2 Microtubule Associated Protein 2, GFAP Glial Fibrillary Acidic Protein, NR NMDA reception
