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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 159 patients

Fig. 4

The pathology findings of the patient with a mixed germ cell tumor (case N12). (a) Increased tumor cell density with abundant mitoses. (b) HE staining showing the teratoma element with cartilage. (cd) MAP2 and S100 positive cells were scattered. (e) Atypically composed neurons of high density and irregular nuclei. (fg) Negative staining for NR1 and moderate positive staining for NR2A. (h) Strongly positive staining for NR2B in cells clustered as a nest. (i) Strong staining for IgG. (j) Plasma cells positive for CD138. (k) Clustered lymphocytes positive for CD20. (l) T-lymphocytes positive for CD3. (m) Helper T lymphocytes positive for CD4. (n) Cytotoxic T lymphocytes positive for CD8. (o-p) Negative staining for CD30 and CD117, which used as marker of embryonal carcinoma and seminoma, dysgerminoma, germinoma. (q-r) Positive staining for CK and negative staining for EMA. (s) Tumor shows strong positive staining for HCG. (t) Isotype control

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