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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 159 patients

Fig. 1

Pathology findings of neural tissues and NMDAR staining in teratomas with anti-NMDARE. Pathology findings of neural tissues in teratomas and NMDAR staining from patients with anti-NMDARE. (a) HE staining showed degenerative neurons. (b) Normal neurons with enlarged nuclei. (c) Neural cells positive for MAP2. (d) Neuroglia positive for GFAP. (e) Neural cells positive for S100. (f) In case N2, IgG positivity is strong and abundant. (g) Plasma cells positive for CD138. (h) and (i) Nodules of lymphocytes positive for CD20 and less positive for CD3, respectively. (j) Less helper T lymphocytes positive for CD4. (k) Cytotoxic T lymphocytes positive for CD8. (l), Isotype control of case N6, (m) Mimicking floating-frog dysmorphic neurons showing positivity for NeuN. (n-p) Moderate NR1/NR2A positivity and strong NR2B positivity in serial sections to M. (q) In case N7, scattered dysmorphic neurons positive for MAP2. (r-t) Moderate NR1 positivity and strong NR2A/NR2B positivity in serial sections to Q. (u) In case N10,clusters dysmorphic neurons positive for NeuN. (v-x) Moderate NR1 positivity and strong NR2A/NR2B positivity in serial sections to U

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Acta Neuropathologica Communications

ISSN: 2051-5960

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