Fig. 3

Spatio-temporal genomic profiling. a. Pathway color-coded representation of gene mutations and selected CNVs: chromatin remodeling – pink; DDR – purple; transcription factors and modulators – green; growth factor receptors and mediators – yellow; other – blue. White boxes lack mutations, and numbers in boxes indicate the number of mutant variants for the respective gene. FFPE microdissected tumor foci are showed in blue font and show decreased TBM for the F5 samples, indicating limited tumor material available for NGS that most likely lowered the mutation and CNV detection rate in these samples. b. Color-coded CNV analysis. c. VAF graphic representation: germline mutations as dots, somatic mutations as bars. FFPE-microdissected samples are shown in blue font and show decreased VAF for the F5 samples