Fig. 1
From: Global activation of oncogenic pathways underlies therapy resistance in diffuse midline glioma
Histologic patterns of tumor cell invasion in DIPG. a. Brain gross appearance. Red and green arrows indicate the primary pontine and the secondary cerebellar foci, respectively. R, right; L, left. b. Sections of indicated brain structures with gross visible tumor foci. Black and blue arrows indicate liquefying necrosis and fleshy tumor, respectively. c. Semiquantitative analysis of histological tumor involvement of the specified color-coded structures. MVP, microvascular proliferation; 4 V, 4th ventricle; PF, posterior fossa; CN, cranial nerve; 3 V, 3rd ventricle; CC, corpus callosum; Temp, temporal; Occip, occipital; WM, white matter; Pyr, pyramidal tracts; IC, internal capsule. The panels and graphs from (b) and (c), respectively, correspond to the brains from (a)