Fig. 1
From: A novel PARD3B-NUTM1 fusion in an aggressive primary CNS embryonal tumor in a young adult
CT and MRI showed a frontotemporal mass with hemorrhage and surrounding vasogenic edema (a, b). Representative histopathology. Low power view shows variegated appearance (c). Small, primitive-appearing tumor cells with some cytoplasmic clearing and hyperchromatic round-to-oval nuclei (d). Spindle cells with ovoid nuclei and myxoid background condensed around a vessel (e). Diffuse uniform nuclear NUT immunostaining (f). A focus of GFAP expression (g). CD99 stains all tumor cells in a membranous or cytoplasmic dot-like pattern (h). Ki-67 proliferative index is high (i). There is nuclear p53 (j) and c-Myc (k) expression in most tumor cells. PARD3B-NUTM1 gene fusion, discovered by NGS of tumor DNA, predicts a fusion protein (l)