Diseases | Etiology | Phenotype(s)a |
---|---|---|
Creutzfeldt-Jakob disease | Sporadic | MM(V)1 (typical/myoclonic variant) VV2 (ataxic/cerebellar or Brownell-Oppenheimer variant) MV2K (kuru-plaque variant) MM(V)2C (cortical variant) VV1 (cortico-striatal variant) Atypical MM1 with PrP-amyloid plaques in white matter |
Genetic | According to PRNP haplotype (mutation + codon 129) and PrPSc type | |
Acquired | I. Iatrogenic (MM1, VV2, MV2K and MMiKb) II. Variant | |
Fatal Insomnia | Sporadic | MM2T (thalamic variant) |
Genetic | Fatal familial insomnia or MM(V)2T (thalamic variant) | |
Gerstmann-Sträussler-Scheinker disease | Genetic | According to PRNP haplotype (mutation + codon 129) and size/s of PrPSc fragment/s |
Variably protease-sensitive prionopathy | Sporadic | According to PRNP codon 129 genotype and PK-resistance of PrPSc fragments |