Table 3 List of differentially expressed genes in the hippocampus of APPPS1 + PLX5622 vs. APP-PS1 control animals: Representative microglia genes and genes involved in the LT signaling pathway were significantly downregulated in APP-PS1 + PLX5622 mice. Genes with a significant adjusted p-value (p < 0.05) are presented in bold
APP-PS1 + PLX5622 vs. APP-PS1 control | |||
|---|---|---|---|
microglia genes | |||
gene | gene description | fold change | adjusted p-value (p < 0.05) |
Mrc1 | mannose receptor, C type 1 | −4.34 | 3.51E-19 |
Tmem119 | transmembrane protein 119 | −2.22 | 4.47E-10 |
Trem2 | triggering receptor expressed on myeloid cells 2 | −1.05 | 3.26E-01 |
Cd68 | CD68 antigen | −0.70 | 2.86E-01 |
Cd33 | CD33 antigen | −1.90 | 4.04E-06 |
Aif1 | allograft inflammatory factor 1 | −1.27 | 2.12E-04 |
leukotrienes signaling pathway | |||
gene | gene description | fold change | adjusted p-value (p < 0.05) |
Alox5ap | arachidonate 5-lipoxygenase activating protein | −1.78 | 2.81E-02 |
Alox5 | arachidonate 5-lipoxygenase | −1.88 | 2.44E-16 |
Lta4h | leukotriene A4 hydrolase | 0.09 | 5.62E-01 |
Ltc4s | leukotriene C4 synthase | −1.36 | 5.05E-01 |
Cysltr1 | cysteinyl leukotriene receptor 1 | −2.23 | 5.48E-07 |
Cysltr2 | cysteinyl leukotriene receptor 2 | 0.75 | 4.50E-01 |
Gpr17 | G protein-coupled receptor 17 | −0.13 | 6.06E-01 |
Syk | spleen tyrosine kinase | −1.32 | 1.44E-07 |
Fcgr1 | Fc receptor, IgG, high affinity I | −1.91 | 3.87E−05 |
Tlr4 | toll-like receptor 4 | -0.67 | 7.90E-02 |
Ncf1 | neutrophil cytosolic factor 1 | −1.84 | 1.41E−03 |
Rgs10 | regulator of G-protein signalling 10 | -0.79 | 2.37E-09 |
Rgs17 | regulator of G-protein signaling 17 | 0.34 | 4.33E-02 |