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Table 2 List of differentially expressed genes in the hippocampus of WT + PLX5622 vs. WT control animals: Representative microglia genes and genes involved in the LT signaling pathway were significantly downregulated in WT + PLX5622 mice. Genes with a significant adjusted p-value (p < 0.05) are presented in bold

From: Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice

WT + PLX5622 vs. WT control

microglia genes

gene

gene description

fold change

adjusted p-value (p < 0.05)

Mrc1

mannose receptor, C type 1

−3.38

6.93E-15

Tmem119

transmembrane protein 119

−2.29

1.25E-10

Trem2

triggering receptor expressed on myeloid cells 2

−1.68

5.83E-02

Cd68

CD68 antigen

−0.88

2.38E-01

Cd33

CD33 antigen

−2.35

3.26E-09

Aif1

allograft inflammatory factor 1

−1.42

3.20E-05

leukotrienes signaling pathway

gene

gene description

fold change

adjusted p-value (p < 0.05)

Alox5ap

arachidonate 5-lipoxygenase activating protein

−1.75

7.70E-14

Alox5

arachidonate 5-lipoxygenase

−1.94

2.68E-02

Lta4h

leukotriene A4 hydrolase

−0.02

9.92E-01

Ltc4s

leukotriene C4 synthase

−0.50

9.87E-01

Cysltr1

cysteinyl leukotriene receptor 1

−1.87

7.59E-05

Cysltr2

cysteinyl leukotriene receptor 2

−0.74

7.77E-01

Gpr17

G protein-coupled receptor 17

−0.12

9.07E-01

Syk

spleen tyrosine kinase

−1.39

1.98E-08

Fcgr1

Fc receptor, IgG, high affinity I

−2.08

1.48E−05

Tlr4

toll-like receptor 4

-0.94

3.78E-03

Ncf1

neutrophil cytosolic factor 1

−1.85

1.92E−03

Rgs10

regulator of G-protein signalling 10

−0.67

1.75E-06

Rgs17

regulator of G-protein signaling 17

-0.10

9.48E-01