WT + PLX5622 vs. WT control | |||
---|---|---|---|
microglia genes | |||
gene | gene description | fold change | adjusted p-value (p < 0.05) |
Mrc1 | mannose receptor, C type 1 | −3.38 | 6.93E-15 |
Tmem119 | transmembrane protein 119 | −2.29 | 1.25E-10 |
Trem2 | triggering receptor expressed on myeloid cells 2 | −1.68 | 5.83E-02 |
Cd68 | CD68 antigen | −0.88 | 2.38E-01 |
Cd33 | CD33 antigen | −2.35 | 3.26E-09 |
Aif1 | allograft inflammatory factor 1 | −1.42 | 3.20E-05 |
leukotrienes signaling pathway | |||
gene | gene description | fold change | adjusted p-value (p < 0.05) |
Alox5ap | arachidonate 5-lipoxygenase activating protein | −1.75 | 7.70E-14 |
Alox5 | arachidonate 5-lipoxygenase | −1.94 | 2.68E-02 |
Lta4h | leukotriene A4 hydrolase | −0.02 | 9.92E-01 |
Ltc4s | leukotriene C4 synthase | −0.50 | 9.87E-01 |
Cysltr1 | cysteinyl leukotriene receptor 1 | −1.87 | 7.59E-05 |
Cysltr2 | cysteinyl leukotriene receptor 2 | −0.74 | 7.77E-01 |
Gpr17 | G protein-coupled receptor 17 | −0.12 | 9.07E-01 |
Syk | spleen tyrosine kinase | −1.39 | 1.98E-08 |
Fcgr1 | Fc receptor, IgG, high affinity I | −2.08 | 1.48E−05 |
Tlr4 | toll-like receptor 4 | -0.94 | 3.78E-03 |
Ncf1 | neutrophil cytosolic factor 1 | −1.85 | 1.92E−03 |
Rgs10 | regulator of G-protein signalling 10 | −0.67 | 1.75E-06 |
Rgs17 | regulator of G-protein signaling 17 | -0.10 | 9.48E-01 |