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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice

Fig. 7

Immunohistochemical analysis of FLAP expression in the hippocampus. a Overall FLAP (green, polyclonal FLAP antibody from Novus Biologicals NBP1–84666) expression was more prominent in APP-PS1 compared to WT control animals and highly reduced with PLX5622 treatment. b FLAP co-localized with Iba1 (white) positive cells in all groups (arrows). Most interestingly, the intensity of FLAP staining in microglia at sites of amyloid plaques was reduced (red asterisk). Dapi was used as nucleus stain. Scale: 50 μm (a), 20 μm (b)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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