Fig. 5From: Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease miceHippocampal transcriptome analysis revealed significantly downregulated microglia genes and downregulated LT signaling related genes in PLX5622 treated mice. a Volcano blots of WT + PLX5622 vs. WT Control and APP-PS1 + PLX5622 vs. APP-PS1 Control (b) comparisons illustrating representative microglia genes (Mrc1, TMEM119, Cd33, Aif1) that were significantly downregulated (adjusted p-value < 0.05) upon microglia cell ablation. Surprisingly, genes involved in the LT signaling pathway (Alox5ap, Alox5, Cysltr1, Syk, Fcgr1, Tlr4, Ncf1, Rgs10) were significantly downregulated in the hippocampus of WT and APP-PS1 mice upon PLX5622 treatment. Blue spots indicate microglia genes; red spots are LTs related genes and grey spots represent all other genesBack to article page