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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice

Fig. 5

Hippocampal transcriptome analysis revealed significantly downregulated microglia genes and downregulated LT signaling related genes in PLX5622 treated mice. a Volcano blots of WT + PLX5622 vs. WT Control and APP-PS1 + PLX5622 vs. APP-PS1 Control (b) comparisons illustrating representative microglia genes (Mrc1, TMEM119, Cd33, Aif1) that were significantly downregulated (adjusted p-value < 0.05) upon microglia cell ablation. Surprisingly, genes involved in the LT signaling pathway (Alox5ap, Alox5, Cysltr1, Syk, Fcgr1, Tlr4, Ncf1, Rgs10) were significantly downregulated in the hippocampus of WT and APP-PS1 mice upon PLX5622 treatment. Blue spots indicate microglia genes; red spots are LTs related genes and grey spots represent all other genes

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