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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function

Fig. 4

Analysis of TDP-43 binding to transcripts dysregulated in Tdp-43 knockdown motoneurons. a Boxplot showing the number of TDP-43 iCLIP counts [18] for upregulated, downregulated and unchanged transcripts in the somatodendritic and axonal compartment after Tdp-43 knockdown. Only transcripts with at least one iCLIP hit were included. *p ≤ 0.05, ****p ≤ 0.0001; Kruskal-Wallis test with Dunn’s multiple comparisons test (N numbers of transcripts are shown in the graph). b Cumulative distribution diagram of the ratio of iCLIP hits in the 3’UTR to the total number of hits. Only transcripts with at least one iCLIP hit in the 3′UTR were included. Transcripts selectively altered in axons of Tdp-43 knockdown motoneurons are labeled “axon only”

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