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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function

Fig. 2

Tdp-43 regulates axon growth of motoneurons. a Immunostaining of motoneurons transduced with a control (shLuc) or different Tdp-43 knockdown (shTdp-43) lentiviruses at DIV7 with antibodies against Tau and GFP. Scale bar: 200 μm. b Quantification of Tdp-43 transcript levels in motoneurons transduced with shRNAs targeting Tdp-43. Bar graphs show Tdp-43 transcript levels relative to control motoneurons transduced with shLuc. Data represent mean ± standard deviation (SD) (n = 4). c Scatter plot showing axon lengths of non-infected motoneurons (w/o virus), control motoneurons transduced with shLuc and Tdp-43 knockdown motoneurons (shTdp-43). Horizontal lines represent median. ***p ≤ 0.001; Kruskal-Wallis-Test (N numbers of axons are shown in the graph, n = 3 independent experiments)

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