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Table 2 Clinical characteristics of patients diagnosed with the four new CNS categories of tumors

From: Molecular identification of CNS NB-FOXR2, CNS EFT-CIC, CNS HGNET-MN1 and CNS HGNET-BCOR pediatric brain tumors using tumor-specific signature genes

ID

Age yrs

Sex

NanoString

diagnosis

Orthogonal

method

Original

diagnosis

Tumor location

Meta-stases

Relapse mts/location

DOD

mts

ADF

mts

Primary treatment

PPNG protocols

RT

Chemiotherapy

CIC 1 ref

0.5

f

EFT-CIC

Methylation

PNET

fronto-temporal right

no

5/distant

9

none

MB/PNET

BCOR 1 ref

1.5

m

HGNET-BCOR

Methylation,

BCOR tandem dup

PNET

frontal right

no

8/local

35

none

MB/PNET

BCOR 2

9

m

HGNET-BCOR

BCOR immuno

GBM

pons

no

29/local

31

local

HGG II version

BCOR 3

6

f

HGNET-BCOR

BCOR immuno

GBM

frontal right

no

no

no

144

local

HGG I version

BCOR 4

6

f

HGNET-BCOR

BCOR tandem dup

GBM

parietal left

no

no

no

168

local

HGG I version

BCOR 5

2.5

f

HGNET-BCOR

BCOR immuno

Unclassified malignant neuroepithelial tumor

cerebellar hemisphere

no

no

no

66

CSI

MB SR

BCOR 6

8

m

HGNET-BCOR

BCOR tandem dup

Anaplastic oligodendroglioma

frontal lobe left

no

22/local

24tox

local

HGG I version

MN1 ref

2

f

HGNET-MN1

Methylation, MN1:BEND2 fusion

PNET

parieto-temporal right

no

no

no

144

none

MB/PNET

MN2

9

f

HGNET-MN1

MN1:BEND2 fusion

EPN

frontal lobe right

no

no

no

204

local

HGG I version

MN3

11

f

HGNET-MN1

MN1:BEND2 fusion

Papillary EPN

parietal left

no

no

no

132

local

none

MN4

6

f

HGNET-MN1

MN1:BEND2 fusion

CPC

parietal right

no

no

no

180

local

CPC

FOXR2 1 ref

5

f

NB-FOXR2

Methylation

PNET

parietal left

yes

no

no

120

CSI

MB/PNET

FOXR2 2 ref

4.5

m

NB-FOXR2

Methylation

PNET

parieto-occipital left

no

no

no

137

CSI

MB/PNET

FOXR2 3

7

m

NB-FOXR2

nd

PNET

frontal right

no

no

no

240

CSI

MB/PNET

  1. ref reference patients, mts months, DOD Died of disease, ADF Alive disease free, 24tox Death from chemotherapy-related toxicity after 24 months, RT Radiotherapy, CSI Cerebrospinal irradiation, PPNG The Polish Pediatric Neurooncology Group, MB/PNET Medulloblastoma/PNET protocol, HGG High grade glioma protocol,
  2. MB SR Medulloblastoma standard risk protocol, CPC Choroid plexus carcinoma protocol, dup Duplication, BCOR immuno BCOR immunohistochemistry, nd Not done