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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: In vivo evidence of exosome-mediated Aβ neurotoxicity

Fig. 3

5xFAD exosomes associate with neuronal mitochondria VDAC1 leading to caspase activation. Representative photomicrographs of (a) WT exosomes and (b) 5xFAD exosomes injected in brains of WT mice showing PLA complex formation (green) inside neurons (blue) in brains injected with 5xFAD exosomes. (c) WT exosomes injection showing no caspase activation, while (d) shows 5xFAD exosome- injected brains showing positive cleaved caspase-3 signals (green) colocalized with labeled exosomes (red)

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