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Table 2 NTRK rearrangements

From: Molecular and clinicopathologic features of gliomas harboring NTRK fusions

Case

Assay detecting NTRK fusion

NTRK fusion

5’ fusion partner breakpoint or transcript

3’ fusion partner breakpoint or transcript

23

DNA-based NGS

ARGLU1-NTRK1

Exon 3

Exon 11

29

DNA-based NGS

ARHGEF11-NTRK1

Exon 39

Exon 10

10

RNA-based fusion panel

ARHGEF2-NTRK1

Exon 21

Exon 10

40

DNA-based NGS

ARHGEF2-NTRK1

Exon 21

Exon 9

27

DNA-based NGS

BCAN-NTRK1

Exon 13

Exon 8

30

DNA-based NGS

BCAN-NTRK1

Exon 6

Exon 8

31

DNA-based NGS

BCAN-NTRK1

Exon 14

Exon 11

32

DNA-based NGS

BCAN-NTRK1

Exon 13

Exon 9

8

DNA-based NGS

CD247-NTRK1

Intron 1

Exon 15

42

DNA-based NGS

CHTOP-NTRK1

Exon 5

Exon 8

21

RNA-based fusion panel

KIF21B-NTRK1a

Unknown

Unknown

9

DNA-based NGS

LMNA-NTRK1

Intron 5

Intron 10

41

DNA-based NGS

LMNA-NTRK1

Exon 12

Exon 11

26

DNA-based NGS

NTRK1-NFASC

Exon 7

Exon 3

24

DNA-based NGS

NOS1AP-NTRK1

Exon 10

Exon 9

33

DNA-based NGS

TPM3-NTRK1

Exon 10

Exon 12

36

DNA-based NGS

TPM3-NTRK1

Exon 7

Exon 12

37

DNA-based NGS

TPM3-NTRK1

Exon 10

Exon 9

38

DNA-based NGS

TPM3-NTRK1

Exon 7

Exon 8

19

RNA-based fusion panel

TPR and NTRK1a,b

Unknown

Unknown

25

DNA-based NGS

AFAP1-NTRK2

Exon 14

Exon 12

11

DNA-based NGS

BCR-NTRK2

Intron 1

Intron 12

28

DNA-based NGS

BCR-NTRK2

Exon 1

Exon 13

5

RNA-based fusion panel

EML1-NTRK2

Exon 2

Exon 16

4

RNA-based fusion panel

GKAP1-NTRK2

Exon 9

Exon 15

15

RNA-based fusion panel

KANK1-NTRK2

Exon 12

Exon 3

16

RNA-based fusion panel

KCTD16-NTRK2

Exon 3

Exon 16

1

RNA-based fusion panel

NBPF20-NTRK2

Exon 16

Exon 15

39

DNA-based NGS

PAIP1-NTRK2

Exon 9

Exon 13

18

RNA-based fusion panel

QKI-NTRK2

Exon 6

Exon 16

2

RNA-based fusion panel

SPECC1L-NTRK2

Exon 11

Exon 17

22

RNA-based NGS

TNS3-NTRK2a

Exon 16

Exon 12

3

RNA-based fusion panel

TRIM24-NTRK2

Exon 12

Exon 15

17

RNA-based fusion panel

TRIM24-NTRK2c

Exon 12

Exon 15, exon 16

34

DNA-based NGS

DLG1-NTRK3

Exon 10

Exon 11

6

RNA-based fusion panel

ETV6-NTRK3

Exon 4

Exon 14

14

RNA-based fusion panel

ETV6-NTRK3

Exon 4

Exon 14

20

DNA-based NGS

ETV6-NTRK3

Intron 4

Intron 12

35

DNA-based NGS

ETV6-NTRK3

Exon 5

Exon 15

12

RNA-based fusion panel

FRY-NTRK3

Exon 1

Exon 14

13

DNA-based NGS

KIAA1199-NTRK3

Intron 1

Intron 5

7

DNA-based NGS

MYO5A-NTRK3

Intron 33

Exon 9

  1. aNTRK rearrangement confirmed by fluorescence in situ hybridization (FISH). b Unknown if NTRK is 5′ or 3′ fusion partner. cTwo NTRK2 fusions detected, with the major form fused to exon 16 of NTRK2 and the minor form fused to exon 15 of NTRK2. NGS Next generation sequencing