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Table 2 NTRK rearrangements

From: Molecular and clinicopathologic features of gliomas harboring NTRK fusions

Case Assay detecting NTRK fusion NTRK fusion 5’ fusion partner breakpoint or transcript 3’ fusion partner breakpoint or transcript
23 DNA-based NGS ARGLU1-NTRK1 Exon 3 Exon 11
29 DNA-based NGS ARHGEF11-NTRK1 Exon 39 Exon 10
10 RNA-based fusion panel ARHGEF2-NTRK1 Exon 21 Exon 10
40 DNA-based NGS ARHGEF2-NTRK1 Exon 21 Exon 9
27 DNA-based NGS BCAN-NTRK1 Exon 13 Exon 8
30 DNA-based NGS BCAN-NTRK1 Exon 6 Exon 8
31 DNA-based NGS BCAN-NTRK1 Exon 14 Exon 11
32 DNA-based NGS BCAN-NTRK1 Exon 13 Exon 9
8 DNA-based NGS CD247-NTRK1 Intron 1 Exon 15
42 DNA-based NGS CHTOP-NTRK1 Exon 5 Exon 8
21 RNA-based fusion panel KIF21B-NTRK1a Unknown Unknown
9 DNA-based NGS LMNA-NTRK1 Intron 5 Intron 10
41 DNA-based NGS LMNA-NTRK1 Exon 12 Exon 11
26 DNA-based NGS NTRK1-NFASC Exon 7 Exon 3
24 DNA-based NGS NOS1AP-NTRK1 Exon 10 Exon 9
33 DNA-based NGS TPM3-NTRK1 Exon 10 Exon 12
36 DNA-based NGS TPM3-NTRK1 Exon 7 Exon 12
37 DNA-based NGS TPM3-NTRK1 Exon 10 Exon 9
38 DNA-based NGS TPM3-NTRK1 Exon 7 Exon 8
19 RNA-based fusion panel TPR and NTRK1a,b Unknown Unknown
25 DNA-based NGS AFAP1-NTRK2 Exon 14 Exon 12
11 DNA-based NGS BCR-NTRK2 Intron 1 Intron 12
28 DNA-based NGS BCR-NTRK2 Exon 1 Exon 13
5 RNA-based fusion panel EML1-NTRK2 Exon 2 Exon 16
4 RNA-based fusion panel GKAP1-NTRK2 Exon 9 Exon 15
15 RNA-based fusion panel KANK1-NTRK2 Exon 12 Exon 3
16 RNA-based fusion panel KCTD16-NTRK2 Exon 3 Exon 16
1 RNA-based fusion panel NBPF20-NTRK2 Exon 16 Exon 15
39 DNA-based NGS PAIP1-NTRK2 Exon 9 Exon 13
18 RNA-based fusion panel QKI-NTRK2 Exon 6 Exon 16
2 RNA-based fusion panel SPECC1L-NTRK2 Exon 11 Exon 17
22 RNA-based NGS TNS3-NTRK2a Exon 16 Exon 12
3 RNA-based fusion panel TRIM24-NTRK2 Exon 12 Exon 15
17 RNA-based fusion panel TRIM24-NTRK2c Exon 12 Exon 15, exon 16
34 DNA-based NGS DLG1-NTRK3 Exon 10 Exon 11
6 RNA-based fusion panel ETV6-NTRK3 Exon 4 Exon 14
14 RNA-based fusion panel ETV6-NTRK3 Exon 4 Exon 14
20 DNA-based NGS ETV6-NTRK3 Intron 4 Intron 12
35 DNA-based NGS ETV6-NTRK3 Exon 5 Exon 15
12 RNA-based fusion panel FRY-NTRK3 Exon 1 Exon 14
13 DNA-based NGS KIAA1199-NTRK3 Intron 1 Intron 5
7 DNA-based NGS MYO5A-NTRK3 Intron 33 Exon 9
  1. aNTRK rearrangement confirmed by fluorescence in situ hybridization (FISH). b Unknown if NTRK is 5′ or 3′ fusion partner. cTwo NTRK2 fusions detected, with the major form fused to exon 16 of NTRK2 and the minor form fused to exon 15 of NTRK2. NGS Next generation sequencing
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