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Table 1 Clinicopathologic characteristics

From: Molecular and clinicopathologic features of gliomas harboring NTRK fusions

Patient characteristics

Total, n (%)

Total Number of Patients

42 (100%)

Demographics

 Sex

  Male

24 (57.1%)

  Female

18 (42.9%)

 Age, median (range), years

24 (<1-81)

  Infantile (≤1), n (%)

7 (16.7%)

  Pediatric (>1 to ≤18), n (%)

13 (31.0%)

  Adult (>18), n (%)

22 (52.4%)

Radiology

 Location

  Hemispheric

28 (66.7%)

  Brainstem/spinal cord

4 (9.5%)

  Cerebellar

3 (7.1%)

  Gliomatosis pattern/widespread

3 (7.1%)

  Optic nerve/suprasellar/deep grey nuclei

2 (4.8%)

  Other/unknown

2 (4.8%)

Survival Data (n=21: 4 infantile, 9 pediatric, 8 adult)

(cases without any available follow-up data excluded)

 Deaths

6 (28.6% of all cases; all HG)

  Infantile

2 (50%)

  Pediatric

0 (0%)

  Adult

4 (50%)

 Tumor Recurrence/Progression

11 (57.9%; 6 HG, 1 LG, 4 of certain WHO grade)a

  Infantile

2 (100%)a

  Pediatric

5 (55.6%)

  Adult

4 (50%)

 Follow-up, median (range), months

23 (4-189)a

  1. aExcludes 2 infantile tumors diagnosed at autopsy
  2. HG High histologic grade, LG Low histologic grade