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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Molecular and clinicopathologic features of gliomas harboring NTRK fusions

Fig. 4

(Top-left) The histologic spectrum of NTRK-fused gliomas can include (a) glioblastoma (GBM), (b) infiltrative low-grade glioma, (c) glioma with anaplastic features and uncertain WHO grade, (d) pilocytic astrocytoma, (e) pleomorphic xanthoastrocytoma, and (f) ganglioglioma. (Top right) Histologic grades of NTRK-fused gliomas: most NTRK-fused gliomas demonstrate high-grade histology, particularly in tumors diagnosed in infant and adult patients. In contrast, the vast majority of NTRK-fused gliomas diagnosed in pediatric patients are of low-grade histology or of uncertain WHO grade. (Bottom) Histologic diagnoses of NTRK-fused gliomas: there were 12 unique histologic diagnoses assigned to NTRK-fused glioma in the study. Slightly less than half of all cases were diagnosed as GBM. Within the infantile and adult age cohorts, the majority of cases were diagnosed as GBM. A more diverse spectrum of tumors was diagnosed in the pediatric age cohort for which there was no single predominant histologic diagnosis

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